Clinical significance of extrapyramidal signs in patients with cirrhosis
Clinical significance of extrapyramidal signs in patients with cirrhosis
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DOI：
10.1016/j.jhep.2004.12.030
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发表时间：
2005-05-01
影响因子：
25.7
通讯作者：
Pérez-Mateo, M
中科院分区：
文献类型：
--
作者：
Jover, R;Compañy, L;Pérez-Mateo, M
背景/目的：锥体外系体征在肝硬化中有描述，但关于其临床意义的信息很少。本研究的目的是探讨锥体外系症状与认知功能障碍的关系及其对生活质量的影响。方法：对46例肝硬化患者进行认知功能障碍的心理测量学测试（线索测验A部分、Growd-Pegboard、积木设计、口头符号数字和Stroop测验）和认知诱发电位（P300）。使用ASTRORS量表评价锥体外系体征。采用SF-36量表和慢性肝病问卷（CLDQ）评定患者的健康相关生活质量（HRQL）。结果：22例患者有锥体外系症状，除区组设计外，其他各项心理测量学测验得分均较低。有锥体外系症状的患者P300潜伏期也较长。此外，锥体外系体征的患者在所有HRQL量表中得分最差。多变量分析显示，唯一的变量显示一个独立的关系，SF-36和CLDQ的精神成分总结是CLDRS score.Conclusions：我们已经发现了锥体外系体征和认知功能障碍之间的存在明确的关系。此外，有锥体外系症状的患者在生活质量量表中的得分更低。(c)2005年欧洲肝脏研究协会。Elsevier B. V.出版，保留所有权利。
Background/Aims: Extrapyramidal signs have been described in cirrhosis and there is little information about their clinical significance. The aims of this study have been to investigate the relationship between extrapyramidal signs and cognitive impairment, and what is their influence on quality of life.Methods: 46 patients with cirrhosis were evaluated for cognitive impairment with psychometric tests (Trail-Making Test part A, Grooved-Pegboard, Block-Design, Oral Symbol Digit and Stroop Test) and cognitive evoked potentials (P300). Extrapyramidal signs were evaluated using the UPDRS scale. Health-related quality of life (HRQL) was measured using SF-36 scale and the Chronic Liver Disease Questionnaire (CLDQ).Results: Twenty-two patients had extrapyramidal signs, and these patients scored worse in all psychometric tests, except Block-Design. Patients with extrapyramidal signs also showed a longer P300 latency. Moreover, patients with extrapyramidal signs had the worst score in all the HRQL scales used. A multivariate analysis disclosed that the only variable showing an independent relationship to the mental component summary of SF-36 and with CLDQ was UPDRS score.Conclusions: We have found a clear relationship between the presence of extrapyramidal signs and cognitive impairment. Moreover, patients with extrapyramidal signs have worse scores in quality of life scales. (c) 2005 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.