Targeted nanoscale therapeutics for myocardial infarction.

Targeted nanoscale therapeutics for myocardial infarction.
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DOI:
10.1039/d0bm01677b
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发表时间:
2021-02-21
影响因子:
6.6
通讯作者:
Christman KL
Christman KL
中科院分区:
工程技术2区
文献类型:
--
作者:
Sullivan HL ;Gianneschi NC ;Christman KL

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纳米级治疗剂有望在心肌梗死后向心脏施用治疗性小分子和生物制剂。使用微创途径直接递送到心脏的梗塞区域对于这一承诺至关重要。在这篇综述中,我们将讨论两个纳米治疗工程的进展和设计考虑,以靶向梗死的心脏,纳米粒子和腺相关病毒。
Nanoscale therapeutics have promise for the administration of therapeutic small molecules and biologics to the heart following myocardial infarction. Directed delivery to the infarcted region of the heart using minimally invasive routes is critical to this promise. In this review, we will discuss the advances and design considerations for two nanoscale therapeutics engineered to target the infarcted heart, nanoparticles and adeno-associated viruses.
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