Resistant hypertension and obstructive sleep apnea in end-stage renal disease.
Resistant hypertension and obstructive sleep apnea in end-stage renal disease.
复制标题
终末期肾病中的顽固性高血压和阻塞性睡眠呼吸暂停。
DOI：
10.1097/hjh.0b013e328352f4c5
复制
发表时间：
2012
影响因子：
4.9
通讯作者：
Campese,VitoM
中科院分区：
文献类型：
--
作者：
Park,Jeanie;Campese,VitoM
(CKD) suffer from substantially higher rates of both resistant hypertension and sleep-disordered breathing, both of which are contributing factors to increased cardiovascular mortality in these populations. The prevalence of obstructive sleep apnea (OSA) increases with declining renal function [1], with an estimated prevalence of around 50% in patients with ESRD [2], which is substantially higher than that in the general population. In this issue of the Journal of Hypertension, Abdel-Kader et al.[3] report an observational study that demonstrates a significant association between resistant hypertension and OSA in patients with ESRD. Resistant hypertension was significantly associated with severe OSA in ESRD (odds ratio 7.1), but no significant association was found between the two disorders in CKD patients not on dialysis, or controls without kidney disease.The connection between hypertension and OSA in the general population has been well described. Patients with OSA are at significantly increased risk of developing hypertension, and the severity of OSA correlates with the level of blood pressure (BP)[2]. The association is even more robust among patients with resistant hypertension and those with severe OSA. In a recent study of 125 consecutive patients with resistant hypertension, nearly two-thirds of the patients had a secondary cause of hypertension, and OSA was by far the most common secondary condition associated with resistant hypertension [4]. Whereas renal parenchymal disease was previously considered the most common identifiable factor associated with resistant
