A RECESSIVE MUTATION, IMMUNE-DEFICIENCY (IMD), DEFINES 2 DISTINCT CONTROL PATHWAYS IN THE DROSOPHILA HOST-DEFENSE
A RECESSIVE MUTATION, IMMUNE-DEFICIENCY (IMD), DEFINES 2 DISTINCT CONTROL PATHWAYS IN THE DROSOPHILA HOST-DEFENSE
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DOI：
10.1073/pnas.92.21.9465
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发表时间：
1995-10-10
影响因子：
11.1
通讯作者：
HOFFMANN, JA
中科院分区：
文献类型：
--
作者：
LEMAITRE, B;KROMERMETZGER, E;HOFFMANN, JA
本文报道了果蝇免疫应答过程中的一种隐性突变--免疫缺陷（imd），它破坏了所有编码抗菌肽基因的诱导。当受到细菌的挑战时，携带这种突变的果蝇的存活率低于野生型果蝇。我们还报道，与抗菌肽相反，抗真菌肽drosomycin在纯合子imd突变背景下仍然是可诱导的。这些结果表明，存在两种不同的途径导致两种类型的靶基因的表达，编码抗菌肽或抗真菌肽drosomycin。
In this paper we report a recessive mutation, immune deficiency (imd), that impairs the inducibility of all genes encoding antibacterial peptides during the immune response of Drosophila. When challenged with bacteria, flies carrying this mutation show a lower survival rate than wild-type flies. We also report that, in contrast to the antibacterial peptides, the antifungal peptide drosomycin remains inducible in a homozygous imd mutant background. These results point to the existence of two different pathways leading to the expression of two types of target genes, encoding either the antibacterial peptides or the antifungal peptide drosomycin.