Clinical utility of the FilmArray meningitis/encephalitis panel in children at a tertiary center in South Korea
Clinical utility of the FilmArray meningitis/encephalitis panel in children at a tertiary center in South Korea
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DOI：
10.1016/j.braindev.2020.08.010
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发表时间：
2021-01-07
影响因子：
1.7
通讯作者：
Lee, Yun-Jin
中科院分区：
文献类型：
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作者：
Park, Su Eun;Lim, Taek Jin;Lee, Yun-Jin
背景：我们通过 FilmArray 脑膜炎/脑炎小组 (FA-MEP) 回顾性评估了小儿脑膜炎/脑炎 (M/E) 脑脊液 (CSF) 中的病原体，以及 FA MEP 结果呈阳性和阴性的儿童的特征。方法：对出现 M/E 症状的儿童进行 FA-MEP 以及常规测试（细菌/病毒培养和聚合酶链反应测试）。回顾临床和实验室数据，以评估 FA-MEP 检测到的病原体儿童的特征。结果：纳入了 110 名儿科 M/E 患者的脑脊液标本。患者的平均年龄为5.9±5.2岁。 FA-MEP总体阳性率为46.4%（51/110）。患者检出的病原体为肠道病毒（23/51，45.1%）、副肠孤病毒（10/51，19.6%）、肺炎链球菌（7/51，13.7%）、人疱疹病毒6型（6/51，11.8%）、无乳链球菌（3/51，5.9%）、单纯疱疹病毒2型(1/51, 2.0%) 和大肠杆菌 (1/51, 2.0%)。无菌性脑膜炎（OR，3.24，95% CI，1.18-12.73）且持续时间
Background: We retrospectively evaluated the pathogens in the cerebrospinal fluid (CSF) of pediatric meningitis/encephalitis (M/E) by FilmArray meningitis/encephalitis panel (FA-MEP), and the characteristics of children showing positive and negative FA MEP results.Method: FA-MEP along with conventional tests (bacterial/viral cultures, and polymerase chain reaction tests) was performed in children who presented symptoms of M/E. Clinical and laboratory data were reviewed to evaluate the characteristics of children with pathogens detected by FA-MEP.Results: The CSF specimens from 110 pediatric M/E patients were enrolled. Mean age of the patients was 5.9 5.2 years. Overall positive rate of FA-MEP was 46.4% (51/110). The pathogens detected in the patients were enterovirus (23/51, 45.1%), parechovirus (10/51, 19.6%), S. pneumoniae (7/51, 13.7%), human herpesvirus type 6 (6/51, 11.8%), S. agalactiae (3/51, 5.9%), herpes simplex virus type 2 (1/51, 2.0%), and E. coli (1/51, 2.0%). Aseptic meningitis (OR, 3.24, 95% CI, 1.18-12.73) and a duration of