Mutation incidence and coincidence in non small-cell lung cancer: meta-analyses by ethnicity and histology (mutMap).
Mutation incidence and coincidence in non small-cell lung cancer: meta-analyses by ethnicity and histology (mutMap).
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DOI：
10.1093/annonc/mdt205
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发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Blowers D
中科院分区：
文献类型：
--
作者：
Dearden S;Stevens J;Wu YL;Blowers D
Meta分析用于描述非小细胞肺癌(NSCLC)的突变发生率模式。对9个突变符合数据最完整的基因进行了评估。一项荟萃分析产生了一个‘MutMap’，以直观地表示按种族(西亚/亚洲)和组织学(腺癌或鳞状细胞癌)突变的一致性。另一项荟萃分析评估了个体突变的发生率。扩展分析探讨了EGFR和KRAS突变的发生率与种族、组织学和吸烟状况的关系。被评估的基因是TP53、EGFR、KRAS、LKB1、EML4-ALK、PTEN、BRAF、PIK3CA和ErbB2。MutMap强调了5%的≥患者中发生的突变符合，包括在ADC患者中出现KRAS或EGFR突变的TP53，以及在西方患者中发生LKB1突变的TP53。TP53基因是突变频率最高的基因。TP53、EGFR、KRAS、LKB1、PTEN和BRAF突变的频率受组织学和/或种族的影响。虽然EGFR突变在来自亚洲的ADC患者和从不/轻度吸烟者中最常见，KRAS突变在ADC患者和来自西方国家的曾经/重度吸烟者中最常见，但这两种突变都是在这些亚群之外检测到的。确定了NSCLC潜在的分子病理节段。有必要对非小细胞肺癌的突变进行进一步研究，以便于更具体的诊断和指导治疗。
Meta-analyses were conducted to characterize patterns of mutation incidence in non small-cell lung cancer (NSCLC). Nine genes with the most complete published mutation coincidence data were evaluated. One meta-analysis generated a ‘mutMap’ to visually represent mutation coincidence by ethnicity (Western/Asian) and histology (adenocarcinoma [ADC] or squamous cell carcinoma). Another meta-analysis evaluated incidence of individual mutations. Extended analyses explored incidence of EGFR and KRAS mutations by ethnicity, histology, and smoking status. Genes evaluated were TP53, EGFR, KRAS, LKB1, EML4-ALK, PTEN, BRAF, PIK3CA, and ErbB2. The mutMap highlighted mutation coincidences occurring in ≥5% of patients, including TP53 with KRAS or EGFR mutations in patients with ADC, and TP53 with LKB1 mutation in Western patients. TP53 was the most frequently mutated gene overall. Frequencies of TP53, EGFR, KRAS, LKB1, PTEN, and BRAF mutations were influenced by histology and/or ethnicity. Although EGFR mutations were most frequent in patients with ADC and never/light smokers from Asia, and KRAS mutations were most frequent in patients with ADC and ever/heavy smokers from Western countries, both were detected outside these subgroups. Potential molecular pathology segments of NSCLC were identified. Further studies of mutations in NSCLC are warranted to facilitate more specific diagnoses and guide treatment.
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影响因子：
51.1
作者：
Mitsudomi, Tetsuya;Morita, Satoshi;Fukuoka, Masahiro
通讯作者：
Fukuoka, Masahiro
影响因子：
51.1
作者：
Zhou, Caicun;Wu, Yi-Long;You, Changxuan
通讯作者：
You, Changxuan
基于组织学和吸烟状况鉴定非小细胞肺癌患者亚组中丰富的驱动基因改变。
影响因子：
3.7
作者：
An SJ;Chen ZH;Su J;Zhang XC;Zhong WZ;Yang JJ;Zhou Q;Yang XN;Huang L;Guan JL;Nie Q;Yan HH;Mok TS;Wu YL
通讯作者：
Wu YL
影响因子：
14.9
作者：
Forbes SA;Bindal N;Bamford S;Cole C;Kok CY;Beare D;Jia M;Shepherd R;Leung K;Menzies A;Teague JW;Campbell PJ;Stratton MR;Futreal PA
通讯作者：
Futreal PA
影响因子：
158.5
作者：
Mok, Tony S.;Wu, Yi-Long;Fukuoka, Masahiro
通讯作者：
Fukuoka, Masahiro