The effects of losartan and enalapril therapies on the levels of nitric oxide, malondialdehyde, and glutathione in patients with essential hypertension
The effects of losartan and enalapril therapies on the levels of nitric oxide, malondialdehyde, and glutathione in patients with essential hypertension
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DOI：
10.2170/jjphysiol.52.435
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发表时间：
2002-10-01
期刊：
影响因子：
--
通讯作者：
Hasanoglu, E
中科院分区：
文献类型：
--
作者：
Donmez, G;Derici, U;Hasanoglu, E
最近的一些研究表明，原发性高血压与氧化应激增加有关，氧化应激可能通过增强氧化和一氧化氮失活而引起高血压。在这项研究中，我们调查了新诊断的原发性高血压患者的丙二醛，一氧化氮和谷胱甘肽水平，以及是否有任何影响的抗高血压治疗血管紧张素11 1型受体拮抗剂，氯沙坦或血管紧张素转换酶抑制剂，依那普利对血浆丙二醛，一氧化氮和谷胱甘肽值。我们选择了17例患者（女性/男性：10/7，平均年龄：46.12 ± 9.2岁）接受依那普利治疗（10- 20 mg/d），14例患者（女性/男性：8/6，平均年龄：47.7 ± 7.5岁）接受氯沙坦治疗（50- 100 mg/d），并与12名正常血压对照组进行比较。在研究开始时，与对照组相比，两个治疗组显示出显著较高的血浆丙二醛和较低的谷胱甘肽和一氧化氮。依那普利和氯沙坦治疗9周后，收缩压和舒张压均显著降低。9周后，依那普利和氯沙坦均显著降低血浆丙二醛，显著升高血浆谷胱甘肽水平和呼出气中一氧化氮。患者组血浆硝酸盐水平的初始值与对照组相似，并且在治疗期后显著增加。总之，氯沙坦和依那普利可能是氧化应激和抗氧化系统之间的调节剂。
Several recent studies have shown that essential hypertension is associated with increased oxidative stress, which may cause hypertension via enhanced oxidation and inactivation of nitric oxide. In this study, we investigated the malondialdehyde, nitric oxide, and glutathione levels in newly diagnosed essential hypertensive patients and whether or not there was any effect of anti hypertensive treatment with angiotensin 11 type 1 receptor antagonist, losartan or angiotensin converting enzyme inhibitor, enalapril on plasma malondialdehyde, nitric oxide, and glutathione values. We selected 17 patients (F/M: 10/7, mean age: 46.12+/-9.2 years) for enalapril therapy (10-20mg/d) and 14 patients (F/M: 8/6, mean age: 47.7+/-7.5 years) for losartan therapy (50-100mg/d), and compared them with 12 normotensive controls. At the be-ginning of the study, both treated groups showed significantly higher plasma malondialdehyde and lower glutathione and nitric oxide in exhaled air compared to the control group. After 9 weeks of enalapril and losartan treatment, both systolic and diastolic pressure were significantly reduced. Both enalapril and losartan produced a significant decrease in plasma malondialdehyde and a significant increase in plasma glutathione levels and nitric oxide in exhaled air after 9 weeks. Initial values of plasma nitrate levels in patient groups were similar to the control group and increased significantly after the treatment period, In conclusion, both losartan and enalapril may be regulators between oxidant stress and the antioxidant system.