Longitudinal myelitis as an initial manifestation of systemic lupus erythematosus.
Longitudinal myelitis as an initial manifestation of systemic lupus erythematosus.
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DOI：
10.1097/00000441-200402000-00011
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发表时间：
2004-02
期刊：
影响因子：
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通讯作者：
Hsian-Cheng Chen;J. Lai;C. Juan;San-Yuan Kuo;Chen-Hung Chen-Chen-Hung-Chen-2201885;D. Chang
中科院分区：
文献类型：
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作者：
Hsian-Cheng Chen;J. Lai;C. Juan;San-Yuan Kuo;Chen-Hung Chen-Chen-Hung-Chen-2201885;D. Chang
摘要横肌萎缩症是系统性红斑狼疮的一种罕见且严重的并发症。脊髓的纵向受累伴狼疮相关的横肌萎缩更少见。仅报告了7例病例。我们报告一位53岁女性，以系统性红斑狼疮合并纵行肌萎缩的初期表现为短期截瘫。随访2年以上，患者对环磷酰胺冲击和大剂量皮质类固醇治疗有部分反应。据我们所知，这是第一例报告的“纵向”肌张力作为初始表现的系统性红斑狼疮。磁共振成像通常表现为T2加权像信号增强、脊髓肿胀和多个脊髓节段的对比度增强。对于无明显病因的截瘫患者，应注意SLE的可能性。
Transverse myelitis is a rare and serious complication of systemic lupus erythematosus (SLE). A longitudinal involvement of the spinal cord with lupus-related transverse myelitis is more unusual. Only 7 cases have been reported. We describe a 53-year-old woman presenting with short-term paraplegia as an initial manifestation of SLE with longitudinal myelitis. She had a partial response to treatment with pulse cyclophosphamide and high-dose corticosteroids after follow-up more than 2 years. To the best of our knowledge, this is the first case report of "longitudinal" myelitis as an initial presentation of SLE. Magnetic resonance imaging typically shows increased signal intensity in T2-weighted images, cord swelling, and contrast enhancement over several spinal segments. The possibility of SLE should be kept in mind in women presenting with paraplegia with no apparent cause.