The effects of an acute psychological stressor on cardiovascular, endocrine, and cellular immune response: a prospective study of individuals high and low in heart rate reactivity.
The effects of an acute psychological stressor on cardiovascular, endocrine, and cellular immune response: a prospective study of individuals high and low in heart rate reactivity.
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DOI：
10.1111/j.1469-8986.1994.tb02215.x
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发表时间：
1994-05
期刊：
影响因子：
3.7
通讯作者：
Sandra Sgoutas-Emch;J. Cacioppo;B. Uchino;W. Malarkey;D. Pearl;J. Kiecolt-Glaser;R. Glaser
中科院分区：
文献类型：
--
作者：
Sandra Sgoutas-Emch;J. Cacioppo;B. Uchino;W. Malarkey;D. Pearl;J. Kiecolt-Glaser;R. Glaser
高和低的反应预选的基础上，他们的心率反应的语音应激在预筛选会议。在主要研究中，受试者暴露于心算加噪音应激源。在基线和应激源期间记录心血管活动，并在应激源之前和之后抽血进行内分泌和免疫测定。结果显示，应激降低了对刀豆球蛋白A的胚化反应，增加了自然杀伤细胞数量和细胞毒性，CD8+ T淋巴细胞的绝对数量，去甲肾上腺素和肾上腺素水平，心率和血压反应。此外，皮质醇和自然杀伤细胞的细胞毒性反应的压力分化个体高与低的心率反应。这些结果表明，自主神经系统，内分泌系统和免疫系统之间的相互作用不仅适合心理生理学分析，但这种分析可能发挥重要作用，阐明潜在的机制。
High and low reactors were preselected on the basis of their heart rate reactivity to a speech stressor in a prescreening session. In the main study, subjects were exposed to a mental arithmetic plus noise stressor. Cardiovascular activity was recorded during baseline and stressor, and blood was drawn prior to and following the stressor for endocrine and immune assays. Results revealed that the stressor decreased the blastogenic response to concanavalin A and increased natural killer cell numbers and cytotoxicity, absolute numbers of CD8+ T-lymphocytes, norepinephrine and epinephrine levels, heart rate, and blood pressure responses. In addition, cortisol and natural killer cell cytotoxicity responses to the stressor differentiated individuals high versus low in heart rate reactivity. These results suggest that the interactions among the autonomic nervous system, endocrine system, and immune system are not only amenable to psychophysiological analysis but that such analyses may play an important role in illuminating underlying mechanisms.