Decreased histamine H1 receptor binding in the brain of depressed patients
Decreased histamine H1 receptor binding in the brain of depressed patients
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DOI：
10.1111/j.1460-9568.2004.03540.x
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发表时间：
2004-08-01
影响因子：
3.4
通讯作者：
Yanai, K
中科院分区：
文献类型：
--
作者：
Kano, M;Fukudo, S;Yanai, K
中枢组胺能神经元系统调节觉醒、睡眠-觉醒周期、食欲控制、学习和记忆以及情绪。先前的研究已经报道了哺乳动物大脑应激条件下神经元组胺释放及其代谢的变化。在这项研究中，我们使用正电子发射断层扫描（PET）和[C-11]-多虑平来研究组胺能神经元系统是否与人类抑郁症有关。采用PET和[C-11]-多虑平检测10例重度抑郁症患者和10例年龄匹配正常受试者的脑组胺H1受体（H1R）结合情况。数据通过逐体素和ROI（兴趣区域）的图形分析来计算。抑郁症患者脑额叶、前额叶皮层和扣带回中[C-11]-多虑平结合电位（BP）值明显低于正常对照组。在抑郁症患者的大脑中，没有哪个区域的[C-11]-多虑平结合明显高于对照组。基于roi的分析还显示，额叶皮层和扣带回中[C-11]-多虑平结合的BP值与自评抑郁量表得分成比例下降。本研究结果表明，抑郁症患者的脑H1R结合减少，并且这种减少与抑郁症症状的严重程度相关。因此，组胺能神经元系统在抑郁症的病理生理中起着重要作用，其调节可能在抑郁症的治疗中被证明是有用的。
The central histaminergic neuron system modulates the wakefulness, sleep-awake cycle, appetite control, learning and memory, and emotion. Previous studies have reported changes in neuronal histamine release and its metabolism under stress conditions in the mammalian brain. In this study, we examined, using positron emission tomography (PET) and [C-11]-doxepin, whether the histaminergic neuron system is involved in human depression. Cerebral histamine H1 receptor (H1R) binding was measured in 10 patients with major depression and in 10 normal age-matched subjects using PET and [C-11]-doxepin. Data were calculated by a graphical analysis on voxel-by-voxel and ROI (region of interests) basis. Binding potential (BP) values for [C-11]-doxepin binding in the frontal and prefrontal cortices, and cingulate gyrus were significantly lower in the depressed patients than those in the normal control subjects. There was no area of the brain where [C-11]-doxepin binding was significantly higher in the depressed patients than in the controls. ROI-based analysis also revealed that BP values for [C-11]-doxepin binding in the frontal cortex and cingulate gyrus decreased in proportion to self-rating depressive scales scores. The results of this study demonstrate that depressed patients have decreased brain H1R binding and that this decrease correlates with the severity of depression symptoms. It is therefore suggested that the histaminergic neuron system plays an important role in the pathophysiology of depression and that its modulation may prove to be useful in the treatment of depression.