Androgen receptor htSNPs in relation to androgen levels and OC use in young women from high-risk breast cancer families
Androgen receptor htSNPs in relation to androgen levels and OC use in young women from high-risk breast cancer families
复制标题
DOI：
10.1016/j.ymgme.2010.09.006
复制
发表时间：
2011-01-01
影响因子：
3.8
通讯作者：
Jernstrom, Helena
中科院分区：
文献类型：
--
作者：
Hietala, Maria;Henningson, Maria;Jernstrom, Helena
高睾丸激素水平与乳腺癌有关。BRCA1可能作为雄激素受体（AR）的共同调节因子。我们旨在研究来自乳腺癌高危家庭的269名年轻健康女性和56名BRCA1/2突变携带者的AR单倍型标记单核苷酸多态性（AR htSNPs）和二倍型与体内雄激素水平、OC联合使用、CAG和GGC基因型以及BRCA1/2/X家族状况的关系。在周期第18-23天测定睾酮、雄烯二酮、硫酸脱氢表雄酮和体体质。6个AR htsnp和CAG和GGC重复长度进行基因分型。大多数OC使用者的雄激素水平低于非使用者(均为p
High testosterone levels have been associated with breast cancer. BRCA1 may function as an androgen receptor (AR) co-regulator. We aimed to examine AR haplotype-tagging single-nucleotide polymorphisms (AR htSNPs) and diplotypes in relation to in vivo androgen levels, combined OC use, CAG and GGC genotypes, and BRCA1/2/X family status in 269 young healthy women from breast cancer high-risk families and 56 additional BRCA1/2 mutation carriers. Testosterone, androstenedione, dehydroepiandrosterone sulfate, and body constitution were measured on cycle days 18-23. Six AR htSNPs and CAG and GGC repeat lengths were genotyped. Most OC users had lower androgen levels than non-users (all Ps