Resistance to intestinal parasites during murine AIDS: role of alcohol and nutrition in immune dysfunction.
Resistance to intestinal parasites during murine AIDS: role of alcohol and nutrition in immune dysfunction.
复制标题
小鼠艾滋病期间对肠道寄生虫的抵抗力：酒精和营养在免疫功能障碍中的作用。
DOI：
10.1017/s003118200007551x
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发表时间：
1993
期刊：
影响因子：
2.4
通讯作者：
Watson,RR
中科院分区：
文献类型：
--
作者：
Watson,RR
一种与人类艾滋病有许多相似之处的小鼠艾滋病模型，LP-BM5小鼠白血病，在肠道中抑制T和B细胞的数量和功能。这允许贾第鞭毛虫和隐孢子虫长期定植。可卡因和营养酒精具有免疫抑制作用，进一步降低了对肠道寄生虫的抵抗力和肠道淋巴细胞数量。蛋白质营养不良、补充维生素E和饮酒进一步改变小鼠逆转录病毒感染引起的免疫功能障碍。这表明营养不足和营养补充都可能影响艾滋病期间寄生虫的耐药性。因此，这种人类艾滋病的小鼠模型具有很大的潜力，可以加速研究营养物质在免疫功能障碍和对肠道寄生虫的抵抗力中的作用。
A murine AIDS model with many similarities to human AIDS, LP-BM5 Murine Leukaemia, suppresses T and B cell numbers and functions in the intestine. This permits chronic colonization by Giardia and Cryptosporidium. Cocaine and the nutrient alcohol, which are immunosuppressive, further reduce resistance to intestinal parasites and intestinal lymphocyte numbers. Protein undernutrition, vitamin E supplementation, and alcohol use further modify immune dysfunction induced by the murine retrovirus infection. This suggests that both undernutrition and nutrient supplementation could affect parasite resistance during AIDS. Thus this murine model of human AIDS has great potential to accelerate studies of the role of nutrients in immune dysfunction and resistance to intestinal parasites.