Total Synthesis of Dictyodendrin A and B
Total Synthesis of Dictyodendrin A and B
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DOI：
10.1002/anie.201001966
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发表时间：
2010-01-01
影响因子：
16.6
通讯作者：
Tokuyama, Hidetoshi
中科院分区：
文献类型：
--
作者：
Okano, Kentaro;Fujiwara, Hideto;Tokuyama, Hidetoshi
（图中所示）火线内：标题化合物的高效全合成的特征在于用于构建高度取代的关键吲哚啉中间体的新型苯炔介导的一锅法吲哚啉形成/交叉偶联序列。然后将外围取代基以模块化的方式引入到中间体上，以完成竹荪素A和B的全合成。
(Figure Presented) In-do-line of fire: A highly efficient total synthesis of the title compounds features a novel benzyne-mediated one-pot indoline formation/cross-coupling sequence for the construction of a highly substituted key indoline intermediate. The peripheral substituents were then introduced onto the intermediate in a modular fashion to complete the total syntheses of dictyodendrin A and B.