Effect of coronary sinus occlusion on coronary pressure-flow relations.
Effect of coronary sinus occlusion on coronary pressure-flow relations.
复制标题
冠状窦闭塞对冠状动脉压力-血流关系的影响。
DOI：
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发表时间：
1980
影响因子：
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通讯作者：
R. W. Baer
中科院分区：
文献类型：
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作者：
R. Bellamy;H. Lowensohn;W. Ehrlich;R. W. Baer
本文研究了在人工延长舒张期，短暂阻断冠状静脉窦对开胸麻醉犬主动脉压与回旋冠脉血流量关系的影响。冠脉压力-流量关系是线性的，血流在动脉压(PF=0)总是超过冠脉静脉压(PCV)时停止。反应性充血时，PCV为5 mm Hg时PF=0为31 mm Hg，冠状静脉窦闭塞时PF=0为52 mm Hg(PCV为38 mm Hg)。PCV的升高将冠脉压力-流量关系转化为较高的Pf=0，而不改变该关系的斜率。Pf=0增加了PCV增加的大约三分之二。我们发现没有证据表明存在PCV水平，低于该水平PCV的变化对冠状动脉压力-流量关系没有影响。这些数据与冠脉循环中血管瀑布机制的存在不相容，除非假设PCV是Pf=0的决定因素之一。
We studied the effect of transient occlusion of the coronary sinus on the relationship between aortic pressure and circumflex coronary blood flow in open-chest anesthetized dog preparations during artificially prolonged diastoles. The coronary pressure-flow relation was linear, and flow stopped at an arterial pressure (Pf = 0) that always exceeded coronary venous pressure (Pcv). During reactive hyperemia, Pf = 0 was 31 mmHg when Pcv was 5 mmHg and increased to 52 mmHg when the coronary sinus was occluded (Pcv, 38 mmHg). Elevation of Pcv translated the coronary pressure-flow relation to a higher Pf = 0 without altering the slope of the relation. Pf = 0 increased by about two-thirds of the increase in Pcv. We found no evidence that there existed a level of Pcv below which changes in Pcv had no effect on the coronary pressure-flow relation. These data are not compatible with the existence of a vascular waterfall mechanism in the coronary circulation unless it is assumed that Pcv is one of the determinants of Pf = 0.