Diffusion tensor imaging of spinocerebellar ataxias types 1 and 2
Diffusion tensor imaging of spinocerebellar ataxias types 1 and 2
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DOI：
10.3174/ajnr.a0716
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发表时间：
2007-11-01
影响因子：
3.5
通讯作者：
Grisoli, M.
中科院分区：
文献类型：
--
作者：
Mandelli, M. L.;De Simone, T.;Grisoli, M.
背景和目的：结构性MR成像不能可靠区分脊髓小脑性共济失调（SCA）1型和2型（SCA 1和SCA 2），并且在症状发作后的最初几年内成像可能正常。我们的目的是确定是否测量的表观扩散系数（ADC）和各向异性分数（FA）可以使其differentiation.MATERIALS和METHODS：我们招募了14例SCA 1，11与SCA 2，和9个年龄匹配的对照。在1.5T扫描机上进行扩散张量成像（DTI），B = 1000 s/mm（2），12个方向。ADC和FA通过感兴趣区域测量，定位于大脑脚水平和脑桥水平的皮质脊髓束，脑桥横纤维，小脑上级和中脚，以及小脑半球白色物质。与对照组相比，SCA 1组小脑中脚和半球白色物质的ADC值显著升高，以及SCA 2所考虑的所有区域。在所审议的所有区域中，SCA 2显著高于SCA 1。关于控制，FA显着减少在SCA 1和SCA 2中考虑的所有区域。SCA 2在脑桥横纤维和大脑脚水平的皮质脊髓束中显著低于SCA 1。结论：DTI不能区分SCA 1和SCA 2。然而，强烈显着差异之间的2个亚型和对照组和临床评分的相关性被发现。
BACKGROUND AND PURPOSE: Structural MR imaging does not enable reliable differentiation of spinocerebellar ataxia (SCA) types 1 and 2 (SCA1 and SCA2), and imaging may be normal during the first years after the onset of symptoms. We aimed at determining whether measurements of the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) may enable their differentiation.MATERIALS AND METHODS: We enrolled 14 patients with SCA1, 11 with SCA2, and 9 age-matched controls. Diffusion tensor imaging (DTI) was performed on a 1.5T scanner, with b = 1000s/mm(2) and 12 directions. ADC and FA were measured by means of regions of interest, positioned in the corticospinal tract at the level of the cerebral peduncle and at the level of the pons, in the transverse pontine fibers, in the superior and middle cerebellar peduncle, and in the hemispheric cerebellar white matter.RESULTS: With respect to controls, the ADC was significantly elevated in the middle cerebellar peduncle and in hemispheric white matter in SCA1, and in all regions under consideration in SCA2. It was significantly higher in SCA2 than in SCA1 in all regions under consideration. With respect to controls, the FA was significantly reduced in all regions under consideration in SCA1 and in SCA2. It was significantly lower in SCA2 than in SCA1 in the transverse pontine fibers and in the corticospinal tract at the level of the cerebral peduncle. Correlations with clinical scores were found.CONCLUSIONS: DTI did not enable differentiation between SCA1 and SCA2. However, strongly significant differences between the 2 subtypes and with respect to controls and correlations with clinical scores were found.