Identification and total synthesis of novel fatty acids from the Caribbean sponge Calyx podatypa
Identification and total synthesis of novel fatty acids from the Caribbean sponge Calyx podatypa
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DOI：
10.1021/np9801413
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发表时间：
1998-08-01
影响因子：
5.1
通讯作者：
Rodríguez, AD
中科院分区：
文献类型：
--
作者：
Carballeira, NM;Pagán, M;Rodríguez, AD
对加勒比海海绵Calyx：podatypa的磷脂脂肪酸组成进行了研究，鉴定出85种不同的脂肪酸，特别是11-甲基十五烷酸和10-三十碳烯酸，这两种脂肪酸没有文献报道。用气相色谱-质谱法对其相应的甲酯和二甲基二硫醚衍生物进行了结构表征。以市售10-羟基十五酸为原料，经全合成(总收率17%)进一步确证了11-甲基十五酸的结构。
The phospholipid fatty acid composition of the Caribbean sponge Calyx: podatypa was studied, and 85 different fatty acids were identified, in particular the 11-methylpentadecanoic acid and 10-tricosenoic acid, which have no literature precedence. Structural characterization was accomplished by means of gas chromatography-mass spectrometry on their corresponding methyl esters and dimethyl disulfide derivatives. The structure of 11-methylpentadecanoic acid was further confirmed by total synthesis (17% overall yield) starting from commercially available 10-hydroxydecanoic acid.