Rhodium Catalyzed Arylation of Diazo Compounds with Aryl Boronic Acids
Rhodium Catalyzed Arylation of Diazo Compounds with Aryl Boronic Acids
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DOI：
10.1021/jo502922r
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发表时间：
2015-04-03
影响因子：
3.6
通讯作者：
Anbarasan, Pazhamalai
中科院分区：
文献类型：
--
作者：
Ghorai, Jayanta;Anbarasan, Pazhamalai
通过铑催化重氮化合物与芳基硼酸的直接芳基化反应，合成了二芳基甲基衍生物乳酸日记酯。该反应可耐受各种硼酸衍生物和官能团。值得注意的是，重氮化合物对其他亲电试剂的化学选择性芳基化被证明。双氯芬辛核心结构的快速合成表明了所开发方法的有效性。
A genetal and efficient synthesis of diary-lacetate, a diarylmethine derivative, was accomplished through rhodium catalyzed direct arylation of diazo compounds with arylboronic acids. The reaction tolerates various boronic acid derivatives and, functional groups. Notably, chemoselective arylation of diazo compounds over other electrophiles were demonstrated. The efficacy of the developed methodology is shown by the expeditious synthesis of the core structure of diclofensine.