Cancer chemotherapy via ambulatory infusion pump
Cancer chemotherapy via ambulatory infusion pump
复制标题
通过流动输液泵进行癌症化疗
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
R. Green
中科院分区：
文献类型：
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作者：
J. Lokich;J. Perri;A. Bothe;T. Zipoli;D. Philips;H. Sonneborn;S. Paul;R. Green
124例恶性肿瘤患者接受4种不同的单药输注方案，持续静脉输注30天或更长时间。通过电池驱动的蠕动泵（Cormed型号ML6）通过锁骨下隧道给药。该方案允许5-Fu的累积药物剂量增加，长春碱的耐受剂量降低，阿霉素和丝裂霉素- c的耐受剂量与标准间歇给药方案相当。所研究的四种药物中有三种观察到治疗效果：5-Fu 13/31结直肠癌；阿霉素7/29;长春碱4/12，黑色素瘤2/4。不良反应明显减少，特别是胃肠道毒性，但阿霉素相关的心脏影响和脱发也减少了。5-Fu治疗晚期结直肠癌和阿霉素治疗特定肿瘤的间歇大剂量治疗与长期输注治疗的III期比较试验正在进行中。动态泵输注（API）化疗在技术上是可行的，并提高了患者对化疗的耐受性，同时显示出类似的抗肿瘤效果。
ONE HUNDRED TWENTY-FOUR PATIENTS with meta-static malignancy were treated with four different single agent infusion programs by constant intravenous infusion for 30 or more days. Drug was administered via a tunneled subclavian line by a battery-driven peristaltic pump (Cormed model ML6) on an ambulatory basis. This schedule allowed for increased cumulative drug dose for 5-Fu, decreased tolerated dose for vinblastine, and comparable doses for adriamycin and mitomycin-C relative to that delivered with the standard intermittent bolus schedule. Therapeutic effects were observed for three of four drugs studied: 5-Fu 13/31 colorectal cancer; adriamycin 7/29; and vinblastine 4/12, including 2/4 melanoma. Adverse effects were significantly reduced, particularly with regard to gastrointestinal toxicity, but also in adriamycin-associated cardiac effects and hair loss. Phase III comparative trials of intermittent bolus therapy with protracted infusion therapy are in progress for 5-Fu in advanced colorectal cancer and for adriamycin in specific tumors. Ambulatory pump infusion (API) chemotherapy is technically feasible and has improved patient tolerance to chemotherapy while demonstrating similar, if not comparable, antitumor effects.