Effects of obesity on pulmonary function considering the transition from obstructive to restrictive pattern from childhood to young adulthood
Effects of obesity on pulmonary function considering the transition from obstructive to restrictive pattern from childhood to young adulthood
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DOI：
10.1111/obr.13327
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发表时间：
2021-07-28
期刊：
影响因子：
8.9
通讯作者：
Lee，Yungling L.
中科院分区：
文献类型：
--
作者：
Huang，Li;Wang，Sen-Te;Lee，Yungling L.
肥胖的成年人表现出限制性的模式，而肥胖的儿童表现出阻塞性的模式。然而，过渡过程仍不明朗。我们对有关儿童体重指数和肺功能的研究进行了系统的搜索。主要观察S用力呼气量(FEV1)、用力肺活量(FVC)及其比值(FEV1/FVC)。我们将超重或肥胖的人与正常体重的人进行了比较。随机效应模型被用来计算合并估计。共纳入17项研究。与正常体重者相比，肥胖者的FEV1/FVC比值较低(平均差值[MD] = −3.61%；95%可信区间[CI] = −4.58%，−2.64%)，预测FVC百分比较高(MD = 3.33%；95%CI = 0.79%，5.88%)。肥胖对儿童至青壮年阻塞性肺功能有损害作用，最大阻塞期为男孩16 ，女孩20 。这种影响在大约30 年龄时减弱，然后在男性35 年龄和女性40 年龄后转变为限制性模式。肥胖对肺功能的影响由儿童期的阻塞型转变为成年期的约束型。
Adults with obesity exhibit a restrictive pattern, whereas children with obesity exhibit an obstructive pattern. However, the transition process remains unclear. We performed a systematic search for studies reporting on body mass index and pulmonary function in children. The main outcomes were forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and their ratio (FEV1/FVC). We compared individuals with overweight or with obesity with individuals with normal weight. Random‐effects models were used to calculate pooled estimates. A total of 17 studies were included. Individuals with obesity had a lower FEV1/FVC ratio (mean difference [MD] = −3.61%; 95% confidence interval [CI] = −4.58%, −2.64%) and a higher percent‐predicted FVC (MD = 3.33%; 95% CI = 0.79%, 5.88%) than those with normal weight. Obesity impaired pulmonary function in the obstructive pattern during childhood to young adulthood, and the maximum obstruction was observed at the age of 16 years in boys and 20 years in girls. The effects attenuated at approximately 30 years and then shifted to the restrictive pattern after 35 years of age in men and 40 years in women. The effects of obesity on pulmonary function change from the obstructive pattern in childhood to the restrictive pattern in adulthood.