Genome analysis of the platypus reveals unique signatures of evolution
Genome analysis of the platypus reveals unique signatures of evolution
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DOI：
10.1038/nature06936
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发表时间：
2008-05-08
期刊：
影响因子：
64.8
通讯作者：
Wilson, Richard K.
中科院分区：
文献类型：
--
作者：
Warren, Wesley C.;Hillier, LaDeana W.;Wilson, Richard K.
我们提出了一个草案的基因组序列的鸭嘴兽，Ornithorhynchus anatinus。这单孔目动物展示了爬行动物和哺乳动物特征的迷人组合。例如，鸭嘴兽有一层适合水生生活方式的皮毛;鸭嘴兽雌性哺乳，但产卵;雄性具有类似爬行动物的毒液。对第一个单孔类基因组的分析将这些特征与遗传创新联系起来。我们发现，爬行动物和鸭嘴兽的毒液蛋白已增选独立于相同的基因家族，乳蛋白基因是保守的，尽管鸭嘴兽产卵，免疫基因家族的扩展直接相关的鸭嘴兽生物学。鉴定了蛋白质、非蛋白质编码RNA和微小RNA家族以及重复元件的扩增。该基因组的测序现在为深入哺乳动物比较分析以及单孔目动物生物学和保护提供了宝贵的资源。
We present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits a fascinating combination of reptilian and mammalian characters. For example, platypuses have a coat of fur adapted to an aquatic lifestyle; platypus females lactate, yet lay eggs; and males are equipped with venom similar to that of reptiles. Analysis of the first monotreme genome aligned these features with genetic innovations. We find that reptile and platypus venom proteins have been co- opted independently from the same gene families; milk protein genes are conserved despite platypuses laying eggs; and immune gene family expansions are directly related to platypus biology. Expansions of protein, non- protein- coding RNA and microRNA families, as well as repeat elements, are identified. Sequencing of this genome now provides a valuable resource for deep mammalian comparative analyses, as well as for monotreme biology and conservation.