Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity
Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity
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DOI：
10.1016/j.febslet.2005.02.055
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发表时间：
2005-04-11
期刊：
影响因子：
3.5
通讯作者：
Ginaldi, L
中科院分区：
文献类型：
--
作者：
De Martinis, M;Franceschi, C;Ginaldi, L
免疫衰老是慢性抗原应激引起的持续磨损的结果。免疫衰老的最重要特征(记忆和效应T细胞的积累、幼稚T细胞的减少、T细胞库的收缩、免疫空间的缩小)与这一假设是一致的。免疫衰老可以作为证据，证明免疫系统在生命早期致力于中和有害物质的有益影响，在生命后期变得有害，这是进化无法预见的时期。这一观点可以解释衰老过程的机制以及与年龄相关的疾病的发病机制。(C)2005年欧洲生化学会联合会。爱思唯尔出版，版权所有。
Immunosenescence is the consequence of the continuous attrition caused by chronic antigenic stress. The most important characteristics of immunosenescence (accumulation of memory and effector T cells, reduction of naive T cells, shrinkage of T cell repertoire, reduction of the immunological space) are compatible with this assumption. Immunosenescence can be taken as proof that the beneficial effects of the immune system, devoted to the neutralization of harmful agents early in life, become detrimental late in life, in a period not foreseen by evolution. This perspective could explain the mechanisms of the ageing process as well as the pathogenesis of age-related diseases. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.