Formulations for delivery of therapeutic proteins
Formulations for delivery of therapeutic proteins
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DOI：
10.1007/s10529-008-9834-y
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发表时间：
2008
影响因子：
2.7
通讯作者：
S. Stolnik;K. Shakesheff
中科院分区：
文献类型：
--
作者：
S. Stolnik;K. Shakesheff
生物技术的进步现在创造了商业规模生产具有治疗活性的蛋白质的能力，为它们在一系列疾病中的应用打开了潜力。目前正在将各种不同的治疗蛋白质转化为临床使用的药物。为了协助这种翻译，运送蛋白质的新配方可能会发挥重要作用。这些新配方需要更充分地满足每种特定蛋白质/多肽的药理和治疗要求，并以这种方式改进现有疗法或增加新条目，扩大目前临床使用的基于蛋白质的药物清单。
Advances in biotechnology have now created a capacity to produce therapeutically active proteins on a commercial scale, opening the potential for their application in an array of disease conditions. The process of translation of the variety of different therapeutic proteins into the medicines used in clinics is now occurring. To assist in this translation, new formulations to deliver proteins could play an important role. These new formulations need to more adequately address the pharmacological and therapeutic requirement for each particular protein/peptide and, in that way, either improve present therapies or extend with new entries the current list of protein based medicines used in clinic.