Lack of α2-adrenergic antilipolytic effect during exercise in subcutaneous adipose tissue of trained men
Lack of α2-adrenergic antilipolytic effect during exercise in subcutaneous adipose tissue of trained men
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DOI：
10.1152/jappl.2001.91.4.1760
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发表时间：
2001-10-01
影响因子：
3.3
通讯作者：
Rivière, D
中科院分区：
文献类型：
--
作者：
De Glisezinski, I;Marion-Latard, F;Rivière, D
本研究的目的是探讨抗脂解α（2）-肾上腺素受体途径在运动过程中腹部皮下脂肪组织（SCAAT）脂肪分解调节中的作用。对 7 名受过训练的人和 15 名未受过训练的人进行了研究。通过使用微透析，在静息时和 50% 最大耗氧量的 60 分钟运动期间，在 SCAAT 中测量细胞外甘油浓度。一根微透析探针用林格溶液灌注；另一种补充了酚妥拉明（α（2）-肾上腺素能受体拮抗剂）。两组之间基线细胞外或血浆甘油浓度没有差异。与未训练的受试者相比，训练过的受试者运动引起的细胞外和血浆甘油增加更高（P < 0.05）。在灌流液中添加酚妥拉明增强了未经训练的受试者中运动诱导的细胞外甘油反应，但在训练过的受试者中则没有增强。运动引起的血浆去甲肾上腺素和肾上腺素浓度升高以及血浆胰岛素浓度降低在两组中没有差异。这些体内研究结果表明，与未经训练的受试者相比，经过训练的受试者有更高的运动诱导脂肪分解，并且表明，在经过训练的受试者中，(2) 介导的抗脂肪分解作用不参与运动期间 SCAAT 中脂肪分解的调节。
The aim of this study was to investigate the involvement of the antilipolytic alpha (2)-adrenergic receptor pathway in the regulation of lipolysis during exercise in subcutaneous abdominal adipose tissue (SCAAT). Seven trained men and 15 untrained men were studied. With the use of microdialysis, the extracellular glycerol concentration was measured in SCAAT at rest and during 60 min of exercise at 50% of maximal oxygen consumption. One microdialysis probe was perfused with Ringer solution; the other was supplemented with phentolamine (alpha (2)-adrenergic receptor antagonist). No differences in baseline extracellular or plasma glycerol concentrations were found between the two groups. The exercise-induced extracellular and plasma glycerol increase was higher in trained compared with untrained subjects (P < 0.05). Addition of phentolamine to the perfusate enhanced the exercise-induced response of extracellular glycerol in untrained subjects but not in trained subjects. The exercise-induced increase in plasma norepinephrine and epinephrine concentrations and the decrease in plasma insulin were not different in the two groups. These in vivo findings demonstrate higher exercise-induced lipolysis in trained compared with untrained subjects and show that, in trained subjects, the (2)-mediated antilipolytic action is not involved in the regulation of lipolysis in SCAAT during exercise.