The development of the corpus callosum in the healthy human brain.
The development of the corpus callosum in the healthy human brain.
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DOI：
10.1523/jneurosci.5122-09.2010
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发表时间：
2010-08-18
期刊：
影响因子：
--
通讯作者：
Toga AW
中科院分区：
文献类型：
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作者：
Luders E;Thompson PM;Toga AW
胼胝体在整个生命过程中都会发生结构性变化，但在儿童和青少年时期变化最大。即便如此，现有的胼胝体发育的研究往往使用包裹方案，可能无法捕捉解剖变化的复杂空间轮廓。因此，更详细的胼胝体生长过程的映射是可取的，以创建一个规范性的参考。这将有助于关联和解释来自健康受试者和儿科患者的其他结构、功能和行为测量。我们应用基于计算表面的网格建模方法来分析胼胝体形态在极高的空间分辨率。我们绘制了胼胝体发育，并探讨了一个大的和良好匹配的样本的健康儿童和青少年（n=190）5至18岁的性别差异。除了在女性的喙，胼胝体厚度增加整个表面，与性别和区域特定的增长率，有时也收缩。胼胝体厚度的时间上明显的变化可能是不同程度的轴突髓鞘形成、重定向和修剪的结果。胼胝体生长和收缩的交替阶段可能反映了儿童和青少年时期连接同源皮质区的纤维的永久性调整和微调。我们的研究结果强调了在未来的研究中考虑性别差异的重要性，因为在合并男性和女性样本时，现有的发育影响可能会被掩盖（或偏向于不平衡统计设计中占主导地位的性别的影响）。
The corpus callosum changes structurally throughout life, but most dramatically during childhood and adolescence. Even so, existing studies of callosal development tend to use parcellation schemes that may not capture the complex spatial profile of anatomical changes. Thus, more detailed mapping of callosal growth processes is desirable to create a normative reference. This will help to relate and interpret other structural, functional, and behavioral measurements, both from healthy subjects and pediatric patients. We applied computational surface-based mesh-modeling methods to analyze callosal morphology at extremely high spatial resolution. We mapped callosal development and explored sex differences in a large and well-matched sample of healthy children and adolescents (n=190) aged 5 to 18 years. Except for the rostrum in females, callosal thickness increased across the whole surface, with sex- and region-specific rates of growth, and also shrinkage at times. The temporally distinct changes in callosal thickness are likely to be a consequence of varying degrees of axonal myelination, redirection, and pruning. Alternating phases of callosal growth and shrinkage may reflect a permanent adjustment and fine-tuning of fibers connecting homologous cortical areas during childhood and adolescence. Our findings emphasize the importance of taking into account sex differences in future studies, as existing developmental effects might remain disguised (or biased towards the effect of the dominant sex in unbalanced statistical designs) when pooling male and female samples.