The microenvironment of the tumour-host interface
The microenvironment of the tumour-host interface
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DOI：
10.1038/35077241
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发表时间：
2001-05-17
期刊：
影响因子：
64.8
通讯作者：
Kohn, EC
中科院分区：
文献类型：
--
作者：
Liotta, LA;Kohn, EC
在癌症发病、进展和转移的整个过程中，局部宿主组织的微环境都是积极的参与者。侵袭发生在肿瘤宿主微生态内，其中基质和肿瘤细胞交换酶和细胞因子，改变局部细胞外基质、刺激迁移并促进增殖和存活。目前正在开发一种针对肿瘤细胞和宿主细胞之间的病理通讯界面的新型癌症疗法。
Throughout the entire process of cancer aetiology, progression and metastasis, the microenvironment of the local host tissue can be an active participant. Invasion occurs within a tumour-host microecology, where stroma and tumour cells exchange enzymes and cytokines that modify the local extracellular matrix, stimulate migration, and promote proliferation and survival. A new class of cancer therapies that targets this pathological communication interface between tumour cells and host cells is currently under development.