The Reversal Characteristics of GABAergic Neurons: A Neurovascular Model.
The Reversal Characteristics of GABAergic Neurons: A Neurovascular Model.
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GABA 能神经元的逆转特征：神经血管模型。
DOI：
10.1115/1.4056336
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
David T
中科院分区：
文献类型：
--
作者：
David T
神经血管耦合（NVC）是一种局部调节血管阻力的能力，是神经元活动的一种功能。最近的实验表明，NVC部分独立于代谢信号。此外，在某些情况下，一氧化氮（NO）在改变血管阻力方面提供了重要的机制。对NVC[1]的原始模型进行了扩展，包括体感觉神经元和GABA能中间神经元的激活，并研究NO的作用以及GABA和神经元肽酶（NPY）途径的微妙平衡。数值模型与小鼠实验数据进行了比较，这些数据提供了氧、脱氧和总血红蛋白的时间依赖性谱。结果表明，当一氧化氮介导的nNOS中间神经元被激活时，GABA和NPY之间存在微妙的平衡。而体感觉神经元（向细胞外空间产生钾）似乎不受NO抑制的影响。当刺激周期从上述实验中使用的2秒短脉冲大幅增加时，需要做进一步的工作来研究NO的作用。
Neurovascular coupling (NVC) is the ability to locally adjust vascular resistance as a function of neuronal activity. Recent experiments have illustrated that NVC is partially independent of metabolic signals. In addition, nitric oxide (NO) has been shown in some instances to provide an important mechanism in altering vascular resistance. An extension to the original model of NVC [1] has been developed to include the activation of both somatosensory neurons and GABAergic interneurons and to investigate the role of NO and the delicate balance of GABA and neuronal peptide enzymes (NPY) pathways. The numerical model is compared to murine experimental data that provides time-dependent profiles of oxy, de-oxy, and total-hemoglobin. The results indicate a delicate balance that exists between GABA and NPY when nNOS interneurons are activated mediated by NO. Whereas somatosensory neurons (producing potassium into the extracellular space) do not seem to be effected by the inhibition of NO. Further work will need to be done to investigate the role of NO when stimulation periods are increased substantially from the short pulses of 2 s as used in the above experiments.