Comparative mutagenic and genotoxic effects of three antimalarial drugs, chloroquine, primaquine and amodiaquine
Comparative mutagenic and genotoxic effects of three antimalarial drugs, chloroquine, primaquine and amodiaquine
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DOI：
10.1093/mutage/13.6.619
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发表时间：
1998-11-01
期刊：
影响因子：
2.7
通讯作者：
Giri, AK
中科院分区：
文献类型：
--
作者：
Chatterjee, T;Muhkopadhyay, A;Giri, AK
采用艾姆斯致突变试验（菌株TA 97 a、TA 100、TA 102和TA 104）和小鼠骨髓细胞体内姐妹染色单体交换（SCE）和染色体畸变（CA）试验，比较了三种抗疟药氯喹、伯氨喹和阿莫地喹的致突变和遗传毒性作用。这些是目前全世界最常用的抗疟药物。细菌致突变性试验的结果显示，所有三种药物在沙门氏菌菌株TA 97a和TA 100（含和不含S9混合物）中以及在TA 104（仅含S9混合物）中的致突变作用非常弱。体内SCE和CA试验结果表明，这三种药物对小鼠骨髓细胞具有遗传毒性。
Comparative mutagenic and genotoxic effects of three antimalarial drugs, chloroquine, primaquine and amodiaquine, were assessed in the Ames mutagenicity assay (in strains TA97a, TA100, TA102 and TA104) and in vivo sister chromatid exchange (SCE) and chromosome aberration (CA) assays in bone marrow cells of mice. These are the most commonly used antimalarial drugs available at present throughout the world. The results of the bacterial mutagenicity assays showed a very weak mutagenic effect of all three drugs in Salmonella strains TA97a and TA100 both with and without S9 mix and in TA104 only with S9 mix. The results of the in vivo SCE and CA assays indicate that these three drugs are genotoxic in bone marrow cells of mice.