miRNAs as biomarkers for early cancer detection and their application in the development of new diagnostic tools.
miRNAs as biomarkers for early cancer detection and their application in the development of new diagnostic tools.
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miRNA作为早期癌症检测的生物标志物及其在新诊断工具开发中的应用。
DOI：
10.1186/s12938-021-00857-9
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发表时间：
2021-02-16
影响因子：
3.9
通讯作者：
Barreto EJSS
中科院分区：
文献类型：
--
作者：
Galvão-Lima LJ;Morais AHF;Valentim RAM;Barreto EJSS
在过去的几十年里，microRNAs （miRNAs）已经成为与人类和其他生物基因表达调控相关的重要分子，扩大了诊断和治疗几种疾病的可用策略。本文系统回顾了与癌症发展相关的mirna文献，并探讨了用于量化这些分子的主要技术及其作为筛选策略的局限性。使用在线数据库PubMed、谷歌Scholar、Web of Science和Science Direct进行文献检索，检索词为“microRNA检测”、“miRNA检测”、“miRNA与前列腺癌”、“miRNA与宫颈癌”、“miRNA与宫颈癌”、“miRNA与乳腺癌”、“miRNA与早期癌症诊断”。在系统评价过程中，报告了26,000多篇已发表的论文，并在应用纳入和排除标准后退回了252篇论文。本研究的目的是确定与癌症发展相关的潜在mirna，这些mirna可能对早期癌症诊断有用，特别是在乳腺癌、前列腺癌和宫颈癌中。此外，我们根据它们在各自癌症发展过程中的相关性提出了一个初步的前20个miRNA面板。考虑到全世界每年新发癌症病例的数量不断增加，开发新的诊断工具对于提高筛查试验的准确性、提高预期寿命和为受影响的患者提供更好的预后至关重要。
Over the last decades, microRNAs (miRNAs) have emerged as important molecules associated with the regulation of gene expression in humans and other organisms, expanding the strategies available to diagnose and handle several diseases. This paper presents a systematic review of literature of miRNAs related to cancer development and explores the main techniques used to quantify these molecules and their limitations as screening strategy. The bibliographic research was conducted using the online databases, PubMed, Google Scholar, Web of Science, and Science Direct searching the terms “microRNA detection”, “miRNA detection”, “miRNA and prostate cancer”, “miRNA and cervical cancer”, “miRNA and cervix cancer”, “miRNA and breast cancer”, and “miRNA and early cancer diagnosis”. Along the systematic review over 26,000 published papers were reported, and 252 papers were returned after applying the inclusion and exclusion criteria, which were considered during this review. The aim of this study is to identify potential miRNAs related to cancer development that may be useful for early cancer diagnosis, notably in the breast, prostate, and cervical cancers. In addition, we suggest a preliminary top 20 miRNA panel according to their relevance during the respective cancer development. Considering the progressive number of new cancer cases every year worldwide, the development of new diagnostic tools is critical to refine the accuracy of screening tests, improving the life expectancy and allowing a better prognosis for the affected patients.
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影响因子：
3
作者：
Cheerla N;Gevaert O
通讯作者：
Gevaert O
影响因子：
--
作者：
Dong H;Luo L;Hong S;Siu H;Xiao Y;Jin L;Chen R;Xiong M
通讯作者：
Xiong M
DOI：
10.1016/j.omtn.2017.06.005
发表时间：
2017-09-15
期刊：
Molecular therapy. Nucleic acids
影响因子：
--
作者：
Chakraborty C;Sharma AR;Sharma G;Doss CGP;Lee SS
通讯作者：
Lee SS
miRNA let-7 对果蝇昼夜节律的调节是由调节周期介导的
影响因子：
16.6
作者：
Chen, Wenfeng;Liu, Zhenxing;Zhao, Zhangwu
通讯作者：
Zhao, Zhangwu
影响因子：
6
作者：
Bao, Lili;Hazari, Sidhartha;Dash, Srikanta
通讯作者：
Dash, Srikanta