Monitoring Wound Health through Bandages with Passive LC Resonant Sensors
Monitoring Wound Health through Bandages with Passive LC Resonant Sensors
复制标题
DOI：
10.1021/acssensors.0c01912
复制
发表时间：
2021-01-22
期刊：
影响因子：
8.9
通讯作者：
Reuel, Nigel F.
中科院分区：
文献类型：
--
作者：
Charkhabi, Sadaf;Jackson, Kyle J.;Reuel, Nigel F.
本文详细介绍了一种嵌入商业敷料中的无源电感电容（LC）谐振传感器，用于低成本，无接触监测伤口;这将能够跟踪愈合过程，同时保持部位封闭和无菌。螺旋LC谐振器由柔性镀铜聚酰亚胺制成，并使用连接到双端口矢量网络分析仪的外部读取器天线进行询问;收集前向传输散射参数（S-21）幅度，并确定谐振频率（MHz）和谐振特征的峰-峰幅度。这些在愈合过程中随着组织的介电常数和电导率的变化而增加。该传感器首先在基于明胶的组织模拟体模上进行了测试，该体模模拟了伤口愈合不同阶段的肌肉、血液、脂肪和皮肤层。还使用有限元建模来验证基于组织的介电特性的预期变化的经验结果。通过使用呈现自然伤口的犬患者以及具有手术施用伤口的大鼠模型的受控队列进行动物研究，研究了用于体内应用的谐振传感器的性能。最后，传递函数的谐振频率与伤口的大小，使用指数模型（R-2 = 0.58-0.96）。然后讨论了传感器设计和制造的后续步骤以及实现通用校准曲线目标的阅读平台。
This paper details a passive, inductor-capacitor (LC) resonant sensor embedded in a commercial dressing for low-cost, contact-free monitoring of a wound; this would enable tracking of the healing process while keeping the site closed and sterile. Spiral LC resonators were fabricated from flexible, copper-coated polyimide and interrogated using external reader antennas connected to a two-port vector network analyzer; the forward transmission scattering parameter (S-21) magnitude was collected, and the resonant frequency (MHz) and the peak-to-peak amplitude of the resonant feature were identified. These increase during the healing process as the permittivity and conductivity of the tissue change. The sensor was first tested on gelatin-based tissue-mimicking phantoms that simulate layers of muscle, blood, fat, and skin at varying phases of wound healing. Finite element modeling was also used to verify the empirical results based on the expected variations in dielectric properties of the tissue. The performance of the resonant sensors for in vivo applications was investigated by conducting animal studies using canine patients that presented with a natural wound as well as a controlled cohort of rat models with surgically administered wounds. Finally, transfer functions are presented that relate the resonant frequency to wound size using an exponential model (R-2 = 0.58-0.96). The next steps in sensor design and fabrication as well as the reading platform to achieve the goal of a universal calibration curve are then discussed.