Cell-Extracellular Matrix Mechanobiology: Forceful Tools and Emerging Needs for Basic and Translational Research.
Cell-Extracellular Matrix Mechanobiology: Forceful Tools and Emerging Needs for Basic and Translational Research.
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DOI：
10.1021/acs.nanolett.7b04982
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发表时间：
2018-01-10
期刊：
影响因子：
10.8
通讯作者：
Saif T
中科院分区：
文献类型：
--
作者：
Holle AW;Young JL;Van Vliet KJ;Kamm RD;Discher D;Janmey P;Spatz JP;Saif T
细胞外生物物理信号对细胞的生长、运动、分化、凋亡、基因表达、粘附和信号转导等行为有着深远的影响。细胞不仅响应于来自细胞外基质（ECM）的明确的机械线索，而且有时还可以改变基质的机械性质，从而影响生理和病理过程中的后续基于基质的线索。体外细胞和材料之间的相互作用可以有意或无意地改变细胞表型和ECM结构。体内细胞和基质力学之间的相互作用在各种各样的疾病中特别重要，包括癌症、中枢神经系统损伤、纤维化疾病和心肌梗死。力学和生物学之间的这种耦合的体外和体内效应对临床应用具有重要意义。
Extracellular biophysical cues have a profound influence on a wide range of cell behaviors, including growth, motility, differentiation, apoptosis, gene expression, adhesion, and signal transduction. Cells not only respond to definitively mechanical cues from the extracellular matrix (ECM) but can also sometimes alter the mechanical properties of the matrix and hence influence subsequent matrix-based cues in both physiological and pathological processes. Interactions between cells and materials in vitro can modify cell phenotype and ECM structure, whether intentionally or inadvertently. Interactions between cell and matrix mechanics in vivo are of particular importance in a wide variety of disorders, including cancer, central nervous system injury, fibrotic diseases, and myocardial infarction. Both the in vitro and in vivo effects of this coupling between mechanics and biology hold important implications for clinical applications.
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DOI：
10.1085/jgp.200409040
发表时间：
2004-09
期刊：
The Journal of general physiology
影响因子：
--
作者：
Browe DM;Baumgarten CM
通讯作者：
Baumgarten CM
影响因子：
10.8
作者：
Deeg J;Axmann M;Matic J;Liapis A;Depoil D;Afrose J;Curado S;Dustin ML;Spatz JP
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Spatz JP
影响因子：
3.7
作者：
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Tanaka TS
影响因子：
3.4
作者：
Ali MY;Chuang CY;Saif MT
通讯作者：
Saif MT
影响因子：
2.9
作者：
Arnold, M;Cavalcanti-Adam, EA;Spatz, JP
通讯作者：
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