Effects of a Traditional Japanese Medicine Goshajinkigan, Tokishigyakukagoshuyushokyoto on the Warm and Cold Sense Threshold and Peripheral Blood Flow
Effects of a Traditional Japanese Medicine Goshajinkigan, Tokishigyakukagoshuyushokyoto on the Warm and Cold Sense Threshold and Peripheral Blood Flow
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日本传统药物“御煞神气丸”对冷热阈值和末梢血流的影响
DOI：
10.4236/health.2014.68097
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发表时间：
2014
期刊：
影响因子：
2.1
通讯作者：
E. Inada
中科院分区：
文献类型：
--
作者：
R. Tsukada;Takuji Yamaguchi;L. Hang;M. Iseki;Hiroyuki Kobayashi;E. Inada
本研究旨在探讨日本传统药物“古沙真气根”（TJ-107）和“tokishigyakukagoshuyusho京都”（TJ-38）对大鼠热感阈值、冷感阈值及外周血流量的影响。健康志愿者31人，对照组9人，TJ-107组12人，tj -38组10人。给药2.5 g一次。在给药1小时前后进行分析。使用热刺激器（Intercross-200, Intercross Co., Tokyo, Japan）测量这些受试者的非手性部位大鱼际的冷热感觉阈值。使用全视野激光灌注成像仪（FLPI, Moor Instruments Ltd., England）测量受试者手指非手性部位的外周血流量。对照组：对热感阈值、冷感阈值及外周血流量无显著影响。TJ-107：热感觉阈值和冷感觉阈值显著降低，冷感觉反应潜伏期显著缩短。第二、三指外周血流量明显增加，分别为115.6%、119.3%。TJ-38：冷感觉阈值和反应潜伏期显著升高。第二、三指外周血流量明显增加，分别增加114.3%、112.8%。提示TJ-107和TJ-38对大鼠热感阈值、冷感阈值的改变和外周血流量的增加均有影响。
The purpose of this study was to investigate the effects of a traditional Japanese medicine Goshajinkigan (TJ-107) and Tokishigyakukagoshuyushokyoto (TJ-38) on warm sense threshold, cold sense threshold and the peripheral blood flow. 31 healthy volunteers (control group: 9people, TJ-107 group: 12 people, TJ-38group:10 people) were examined. Drugs administered 2.5 g a dose. Analysis was before and after 1 hour dosage. The warm and cold sense threshold in the thenar of the non-handedness site of these subjects was measured using a thermostimulator (Intercross-200, Intercross Co., Tokyo, Japan). The peripheral blood flow in the finger of the non-handedness site of these subjects was measured using a full-field laser perfusion imager (FLPI, Moor Instruments Ltd., England). Control: The vehicle had no significant effect on the warm sense threshold, cold sense threshold and the peripheral blood flow. TJ-107: The warm sense threshold and cold sense threshold were significantly decreased, and the reaction latency of cold sense was significantly shortening. The peripheral blood flow was significantly increased second and third finger at 115.6%, 119.3%, respectively. TJ-38: The cold sense threshold and the reaction latency of cold sense were significantly increased. The peripheral blood flow was significantly increased second and third finger with 114.3%, 112.8%, respectively. These results suggest that TJ-107 and TJ-38 have effects on the changed warm sense threshold, cold sense threshold and increased peripheral blood flow.
影响因子：
2.7
作者：
Joo-Young Lee;Mohamed Saat;Chin-Mei Chou;N. Hashiguchi;Titis Wijayanto;Hitoshi Wakabayashi;Y. Tochihara
通讯作者：
Joo-Young Lee;Mohamed Saat;Chin-Mei Chou;N. Hashiguchi;Titis Wijayanto;Hitoshi Wakabayashi;Y. Tochihara