IL-15, A NOVEL T-CELL GROWTH-FACTOR THAT SHARES ACTIVITIES AND RECEPTOR COMPONENTS WITH IL-2
IL-15, A NOVEL T-CELL GROWTH-FACTOR THAT SHARES ACTIVITIES AND RECEPTOR COMPONENTS WITH IL-2
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DOI：
10.1002/jlb.57.5.763
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发表时间：
1995-05-01
影响因子：
5.5
通讯作者：
COSMAN, D
中科院分区：
文献类型：
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作者：
GIRI, JG;ANDERSON, DM;COSMAN, D
白细胞介素15是一种新发现的细胞因子，其与IL-2具有相同的生物学活性，并且与IL-2一样，是四螺旋束细胞因子家族的成员。我们已经表明IL-15与IL-2的受体具有相同的组分：IL-2 R的α链不是必需的，但IL-15介导的生物活性需要β和γ链，因此，IL-15信号传导中的缺陷可能导致人类中X连锁严重联合免疫缺陷的表型，这是由共同γ链中的突变引起的。细胞结合和应答IL-2和IL-15的不同能力表明存在额外的IL-15特异性受体组分，我们鉴定了小鼠T细胞上的IL-15特异性结合蛋白（IL-15 R α）并分离了相应的cDNA。IL-15 R α不是造血细胞生成素受体超家族的成员，但在结构上与IL-2 R的α链相关。与IL-2系统相比，IL-15及其受体的表达模式的差异表明IL-15的独特体内作用。
Interleukin 15 is a newly discovered cytokine that shares biological activities with IL-2 and, like IL-2, is a member of the four-helix bundle cytokine family, We have shown that IL-15 shares components of the receptor for IL-2: the alpha chain of the IL-2R is not required, but both the beta and gamma chains are needed for IL-15 mediated bioactivities, A defect in IL-15 signaling may therefore contribute to the phenotype of X-linked severe combined immunodeficiency in humans, resulting from mutations in the common gamma chain, Differential ability of cells to bind and respond to IL-2 and IL-15 suggested the existence of an additional IL-15 specific receptor component, We identified an IL-15 specific binding protein (IL-15R alpha) on a murine T cell and isolated the corresponding cDNA, The IL-15R alpha is not a member of the hematopoietin receptor superfamily, but is structurally related to the a chain of the IL-2R. Differences in the expression pattern of IL-15 and its receptor compared to the IL-2 system suggest unique in vivo roles for IL-15.