Towards regenerative therapy for cardiac disease
Towards regenerative therapy for cardiac disease
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DOI：
10.1016/s0140-6736(12)60075-0
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发表时间：
2012-03-10
期刊：
影响因子：
168.9
通讯作者：
Chien, Kenneth R.
中科院分区：
文献类型：
--
作者：
Ptaszek, Leon M.;Mansour, Moussa;Chien, Kenneth R.
开发再生治疗策略以逆转晚期心力衰竭的进展是本世纪最紧迫的临床需求之一。从成人干细胞临床试验中获得的见解，以及心脏干细胞和再生生物学方面的基础科学进展，正开始为再生疗法产生潜在的新靶点和战略。尤其重要的是与内在心脏再生有关的新科学发现，可以触发再生的更新因子，以及组织工程技术，这些技术正开始改变研究人员看待心血管再生治疗的科学和临床地位的方式。
Development of regenerative therapeutic strategies to reverse the progression of advanced heart failure is one of the most urgent clinical needs of this century. Insights gained from clinical trials of adult stem cells, together with fundamental scientific advances in cardiac stem cell and regenerative biology, are beginning to yield potential new targets and strategies for regenerative therapies. Of particular importance are new scientific discoveries related to intrinsic cardiac regeneration, renewal factors that can trigger regeneration, and tissue-engineering technology, which are beginning to change the way investigators view the scientific and clinical position of cardiovascular regenerative therapy.