Thalamic-Caudal Zona Incerta Deep Brain Stimulation for Refractory Orthostatic Tremor: A Report of 3 Cases.
Thalamic-Caudal Zona Incerta Deep Brain Stimulation for Refractory Orthostatic Tremor: A Report of 3 Cases.
复制标题
丘脑尾部未定带深部脑刺激治疗难治性直立性震颤：附 3 例报告。
DOI：
10.1002/mdc3.12345
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发表时间：
2017
影响因子：
4
通讯作者：
Athauda D
中科院分区：
文献类型：
--
作者：
Athauda D
直立性震颤（OT）是一种罕见的致残性运动障碍，其特征是下肢发生高频震颤，站立时感觉不稳，迫使患者坐下或行走。药物治疗往往不能令人满意。以前的报告表明，丘脑腹侧中间核的脑深部刺激可能会改善临床结果。作者报告了3例患有顽固性直立性震颤的患者，通过丘脑腹侧中间核-尾侧三叉神经节的双侧脑深部刺激治疗，导致症状改善和持续临床改善，尽管基础震颤频率或发作没有明显变化。
Orthostatic tremor (OT) is a rare, disabling movement disorder characterized by the development of a high‐frequency tremor of the lower limbs and feelings of unsteadiness upon standing, which compel the patient to sit down or walk. Medical therapy is often unsatisfactory. Previous reports suggest that deep brain stimulation of the ventral intermediate nucleus of the thalamus may improve clinical outcomes. The authors report 3 patients who had intractable orthostatic tremor treated with bilateral deep brain stimulation of the ventral intermediate nucleus of the thalamus‐caudal zona incerta, resulting in improved and sustained clinical improvements in symptoms, although there were no apparent changes in the underlying tremor frequency or onset.