Therapeutic application of apoptosis signal-regulating kinase 1 inhibitors
Therapeutic application of apoptosis signal-regulating kinase 1 inhibitors
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DOI：
10.1016/j.jbior.2017.10.004
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发表时间：
2017-12-01
影响因子：
--
通讯作者：
Fujisawa, Takao
中科院分区：
文献类型：
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作者：
Fujisawa, Takao
凋亡信号调节激酶1（Apoptosis signal-regulating kinase 1，ASK 1）是应激活化的丝裂原活化蛋白激酶（MAPK 3 K）家族的成员。ASK 1是一个有吸引力的药物靶标，因为它在包括神经退行性疾病、炎性疾病和癌症在内的多种人类疾病中起着重要作用。最近的研究表明，使用小分子ASK 1抑制剂的药理学操作可能在实验性人类疾病模型中是有益的。在这篇综述中，我们强调了目前对ASK 1抑制剂作为人类疾病潜在治疗方法的理解。
Apoptosis signal-regulating kinase 1 (ASK1) is a member of the stress-activated mitogen-activated protein kinase kinase kinase (MAP3K) family. ASK1 is an attractive drug target, owing to its essential role in a wide variety of human diseases including neurodegenerative disorders, inflammatory diseases and cancer. Recent studies have suggested that pharmacological manipulations using small molecule ASK1 inhibitors may be beneficial in experimental human disease models. In this review, we highlight the current understanding of ASK1 inhibitors as a potential therapy for human diseases.