Cell cycle activation and spinal cord injury.
Cell cycle activation and spinal cord injury.
复制标题
DOI：
10.1007/s13311-011-0028-2
复制
发表时间：
2011-04
影响因子：
5.7
通讯作者：
Faden, Alan I.
中科院分区：
文献类型：
--
作者：
Wu, Junfang;Stoica, Bogdan A.;Faden, Alan I.
关键词：
创伤性脊髓损伤 (SCI) 会引发一系列复杂的事件，最初的机械损伤导致继发性损伤过程，导致进一步的组织损失和功能损伤。越来越多的证据表明 SCI 后细胞周期被激活。损伤后细胞周期蛋白的上调似乎不仅导致有丝分裂后细胞（包括神经元和少突胶质细胞）的凋亡细胞死亡，而且还导致创伤后神经胶质细胞增生和小胶质细胞激活。抑制关键细胞周期调控途径可减少损伤诱导的细胞死亡，以及体外和体内小胶质细胞和星形胶质细胞的增殖。在啮齿动物 SCI 模型中使用细胞周期抑制剂治疗可防止神经元细胞死亡并减少炎症以及周围的神经胶质疤痕，从而显着减少病变体积并改善运动恢复。在这里，我们回顾了 SCI 对细胞周期途径的影响，以及细胞周期抑制剂对该疾病的治疗潜力和作用机制。
Traumatic spinal cord injury (SCI) evokes a complex cascade of events with initial mechanical damage leading to secondary injury processes that contribute to further tissue loss and functional impairment. Growing evidence suggests that the cell cycle is activated following SCI. Up-regulation of cell cycle proteins after injury appears to contribute not only to apoptotic cell death of postmitotic cells, including neurons and oligodendrocytes, but also to post-traumatic gliosis and microglial activation. Inhibition of key cell cycle regulatory pathways reduces injury-induced cell death, as well as microglial and astroglial proliferation both in vitro and in vivo. Treatment with cell cycle inhibitors in rodent SCI models prevents neuronal cell death and reduces inflammation, as well as the surrounding glial scar, resulting in markedly reduced lesion volumes and improved motor recovery. Here we review the effects of SCI on cell cycle pathways, as well as the therapeutic potential and mechanism of action of cell cycle inhibitors for this disorder.
登录
查看更多内容
DOI：
10.1073/pnas.0611671104
发表时间：
2007-02-27
影响因子：
11.1
作者：
Hoeglinger, Guenter U.;Breunig, Joshua J.;Hunot, Stephane
通讯作者：
Hunot, Stephane
影响因子：
4.7
作者：
Faden, AI;Movsesyan, VA;Cernak, B
通讯作者：
Cernak, B
影响因子：
2.7
作者：
ABRAHAM, RT;ACQUARONE, M;VERLHAC, MH
通讯作者：
VERLHAC, MH
影响因子：
3.2
作者：
Jordan-Sciutto, KL;Dorsey, R;Achim, CL
通讯作者：
Achim, CL
影响因子：
4.8
作者：
Giovanni, A;Wirtz-Brugger, F;Park, DS
通讯作者：
Park, DS