Dispersible chitosan particles showing bacteriostatic effect against Streptococcus mutans and their dental polishing effect
Dispersible chitosan particles showing bacteriostatic effect against Streptococcus mutans and their dental polishing effect
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可分散壳聚糖颗粒对变形链球菌具有抑菌作用及其牙齿抛光作用
DOI：
10.1080/09168451.2020.1723402
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Ihara Hirotaka
中科院分区：
文献类型：
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作者：
Saita Kanako;Nagaoka Shoji;Shirosaki Tomohiro;Horikawa Maki;Ihara Hirotaka
无毒且可生物降解的壳聚糖在各种应用中具有潜在的用途。我们利用静电相互作用相分离方法制备了在水溶液中具有高溶解度的亚微米壳聚糖颗粒，但使用柠檬酸代替硫酸钠作为多价阴离子化合物。亚微米壳聚糖颗粒对变形链球菌具有显著的抗菌活性和抗粘附作用，即使在中性pH值附近，但壳聚糖颗粒在相同条件下无抗菌活性。将壳聚糖颗粒添加到牙齿抛光膏中提供了比没有添加剂的抛光膏具有更光滑表面的不锈钢盘（与牙釉质相同的硬度）。鉴于其亚微米尺寸和抗菌活性，壳聚糖颗粒可能是口腔和牙齿清洁材料的多功能组分。
Nontoxic and biodegradable chitosan is potentially useful in various applications. We prepared submicron chitosan particles with high dispersibility in aqueous solution utilizing the electrostatic interaction phase separation method described in a previous report, but using citric acid as the polyvalent anionic compound instead of sodium sulfate. The submicron chitosan particles showed significant antibacterial activity and anti-adhesive action againstStreptococcus mutans, even at around neutral pH. However, chitosan granules showed no antibacterial activity under the same conditions. The addition of the chitosan particles to dental polishing paste provided stainless steel discs (the same hardness as dental enamel) with a smoother surface than polishing paste without additives. In view of their submicron size and antibacterial activity, chitosan particles could potentially be multifunctional components of oral and dental cleaning materials.