F Wave Study in Amyotrophic Lateral Sclerosis: Assessment of Segmental Motoneuronal Dysfunction.
F Wave Study in Amyotrophic Lateral Sclerosis: Assessment of Segmental Motoneuronal Dysfunction.
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DOI：
10.4103/0366-6999.159346
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发表时间：
2015-07-05
影响因子：
6.1
通讯作者：
Ding QY
中科院分区：
文献类型：
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作者：
Fang J;Cui LY;Liu MS;Guan YZ;Li XG;Cui B;Ding QY
脊髓环路功能障碍可能在肌萎缩侧索硬化症(ALS)的病理生理学中起一定作用。本研究的目的是利用F波评估ALS患者上运动神经元(UMN)功能障碍后的节段性运动神经元兴奋性。本文对82例肌萎缩侧索硬化症患者小指展肌152条尺神经的F波进行了研究。根据同一上肢是否有锥体征来定义两组手。上肢锥体征组为P组，上肢无锥体征组为NP组。P组F波波幅均值(P<；0.001)、中位数(P<；0.001)和最大值(P=0.035)、平均(P<；0.001)、中位数(P<；0.001)和最大值(P=0.003)、指标重复神经元(P<；0.001)和指标重复F波(P<；0.001)均显著高于正常对照组。两组F波时间离散度(P=0.628)、平均F波潜伏期(P=0.151)、最小F波潜伏期(P=0.211)、最大F波潜伏期(P=0.199)、F波持续时间(P=0.738)、F波时限(P=0.152)、F波传导速度(P=0.813)和巨大F波数(P=0.072)比较，差异均无统计学意义。在本研究中，肌萎缩侧索硬化症患者的F波波幅、F/M波幅比和中继器F波数的增加反映了UMN功能障碍后节段性运动神经元兴奋性的增强。
Dysfunctional spinal circuit may play a role in the pathophysiology of amyotrophic lateral sclerosis (ALS). The purpose of this study was to use F waves for assessment of segmental motoneuronal excitability following upper motor neuron (UMN) dysfunctions in ALS. We studied the F waves of 152 ulnar nerves recorded from abductor digiti minimi in 82 patients with ALS. Two groups of hands were defined based on the presence or absence of pyramidal signs in the same upper limb. The group with pyramidal signs in the upper limbs was designated as the P group, and the group without pyramidal signs in the upper limbs was designated as the NP group. The mean (P < 0.001), median (P < 0.001) and maximum (P = 0.035) F wave amplitudes, mean (P < 0.001), median (P < 0.001) and maximum (P = 0.003) F/M amplitude ratio, index repeating neuron (P < 0.001) and index repeater F waves (P < 0.001) of the P group were significantly increased compared with the NP group. No significant differences were identified for F wave chronodispersion (P = 0.628), mean F wave latency (P = 0.151), minimum F wave latency (P = 0.211), maximum F wave latency (P = 0.199), F wave persistence (P = 0.738), F wave duration (P = 0.152), F wave conduction velocity (P = 0.813) and number of giant F waves (P = 0.072) between the two groups. In this study, increased F wave amplitude, F/M amplitude ratio and number of repeater F waves reflected enhanced segmental motoneuronal excitability following UMN dysfunctions in ALS.