The Heme Connection: Linking Erythrocytes and Macrophage Biology.
The Heme Connection: Linking Erythrocytes and Macrophage Biology.
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血红素连接：连接红细胞和巨噬细胞生物学。
DOI：
10.3389/fimmu.2017.00033
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发表时间：
2017
影响因子：
7.3
通讯作者：
Haldar M
中科院分区：
文献类型：
--
作者：
Alam MZ;Devalaraja S;Haldar M
红细胞的功能和发育与巨噬细胞密切相关。红细胞的主要功能是氧气输送，其由含铁血红蛋白介导。这种铁的主要来源是循环途径，其中巨噬细胞吞噬和破坏红细胞以释放血红素部分中所含的铁。巨噬细胞还通过在骨髓中提供支持性小生境作为“成红细胞岛”的组成部分来促进红细胞生成。重要的是，炎症导致巨噬细胞处理铁的改变，对铁稳态和红细胞生成产生显著影响。巨噬细胞在红细胞生成和铁稳态中的重要性已得到充分证实，并已被广泛综述。然而，这种发育关系不是单向的，红细胞也可以调节巨噬细胞的发育和功能。红细胞来源的血红素可以诱导单核细胞发育成铁回收巨噬细胞，参与模式识别受体激活巨噬细胞，并作为特异性核受体的配体调节巨噬细胞功能。在这里，我们讨论血红素作为影响巨噬细胞稳态的信号分子的作用。我们将审查这些行动的血红素的框架内，我们目前的理解，微环境因素在巨噬细胞的发展和功能的作用。
Erythroid function and development is intimately linked to macrophages. The primary function of erythrocytes is oxygen delivery, which is mediated by iron-containing hemoglobin. The major source of this iron is a recycling pathway where macrophages scavenge old and damaged erythrocytes to release iron contained within the heme moiety. Macrophages also promote erythropoiesis by providing a supportive niche in the bone marrow as an integral component of “erythorblastic islands.” Importantly, inflammation leads to alterations in iron handling by macrophages with significant impact on iron homeostasis and erythropoiesis. The importance of macrophages in erythropoiesis and iron homeostasis is well established and has been extensively reviewed. However, this developmental relationship is not one way, and erythrocytes can also regulate macrophage development and function. Erythrocyte-derived heme can induce the development of iron-recycling macrophages from monocytes, engage pattern recognition receptors to activate macrophages, and act as ligand for specific nuclear receptors to modulate macrophage function. Here, we discuss the role of heme as a signaling molecule impacting macrophage homeostasis. We will review these actions of heme within the framework of our current understanding of the role of micro-environmental factors in macrophage development and function.