Genetic analysis of H-2 linked gene(s) affecting early mouse embryo development.
Genetic analysis of H-2 linked gene(s) affecting early mouse embryo development.
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影响小鼠早期胚胎发育的 H-2 连锁基因的遗传分析。
DOI：
10.1111/j.1744-313x.1982.tb00966.x
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Warner,CM
中科院分区：
文献类型：
--
作者：
Goldbard,SB;Verbanac,KM;Warner,CM
The number of cells in preimplantation mouse embryos of differentH‐2haplotypes was analysed. It was found that embryos of theH‐2khaplotype have fewer cells per embryo than those of theH‐2bhaplotype. By analysing reciprocal congenic pairs of mice it was demonstrated unequivocally that slow development is linked to theH‐2khaplotype and fast development to theH‐2bhaplotype. The gene(s) in theH‐2complex which influence early mouse embryo development have been namedPed: preimplantation embryo development. Analysis of F1hybrid embryos showed that fast development is dominant. Reciprocal F1crosses yielded identical results, which indicated there was no apparent effect of the maternal egg cytoplasm onPedgene expression. Analysis of F2and back‐cross embryos was consistent with the interpretation that there is a major gene located in theH‐2complex (Ped), which is modified by environment and genetic background, that influences early mouse embryo development.
