Comparison of Fourier-Domain and Time-Domain Optical Coherence Tomography in the Detection of Band Atrophy of the Optic Nerve
Comparison of Fourier-Domain and Time-Domain Optical Coherence Tomography in the Detection of Band Atrophy of the Optic Nerve
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DOI：
10.1016/j.ajo.2008.07.020
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发表时间：
2009-01-01
影响因子：
4.2
通讯作者：
Monteiro, Mario L. R.
中科院分区：
文献类型：
--
作者：
Costa-Cunha, Luciana V. F.;Cunha, Leonardo P.;Monteiro, Mario L. R.
目的：比较傅立叶域(FD)光学相干断层扫描(3D OCT-1000，TOP，CON，日本东京)和时间域(TD)OCT(Stratus，Carl Zeiss Meditec Inc，Dublin，California，California)对视神经带萎缩(BA)患者轴突丢失的检测能力。设计：横断面研究。方法：对36例(36只眼)因视交叉受压而出现颞叶视野(VF)缺陷的BA患者和36只正常眼进行研究。受试者接受标准的自动视野检查，并使用3D OCT-1000和Stratus OCT测量黄斑和视网膜神经纤维层(RNFL)。计算每个参数的受试者工作特征(ROC)曲线。获得Spearman相关系数，以评估RNFL与黄斑厚度参数和VF丢失严重程度的关系。结果：无论使用何种OCT设备，BA患者的RNFL和黄斑厚度参数均显著低于正常眼，但ROC曲线下面积差异无统计学意义。这两种设备的结构-功能关系也是相似的。在两组中，3D OCT-1000的RNFL和黄斑厚度测量普遍小于Stratus OCT，在某些情况下明显小于Stratus OCT。结论：在使用制造商目前提供的软件时，引入FD技术并不会导致与TD技术相比，对视神经BA的区分能力更好。3DOCT-1000FD、OCT、RNFL和黄斑测量一般小于TD层OCT测量。调查人员在比较使用这两种设备获得的测量结果时应该意识到这一事实。Am J Oplathalmol2009；147：56-63。(C)2009，由Elsevier Inc.保留所有权利。)
PURPOSE: To compare the ability of Fourier-domain (FD) optical coherence tomography (3D OCT-1000; Top, con, Tokyo, Japan) and time domain (TD) OCT (Stratus; Carl Zeiss Meditec Inc, Dublin, California, USA) to detect axonal loss in eyes with band atrophy (BA) of the optic nerve.DESIGN: Cross-sectional study.METHODS: Thirty-six eyes from 36 patients with BA and temporal visual field (VF) defect from chiasmal compression and 36 normal eyes were studied. Subjects were submitted to standard automated perimetry and macular and retinal nerve fiber layer (RNFL) measurements were taken using 3D OCT-1000 and Stratus OCT. Receiver operating characteristic (ROC) curves were calculated for each parameter. Spearman correlation coefficients were obtained to evaluate the relationship between RNFL and macular thickness parameters and severity of VF loss. Measurements from the two devices were compared.RESULTS: Regardless of OCT device, all RNFL and macular thickness parameters were significantly lower in eyes with BA compared with normal eyes, but no statistically significant difference was found with regard to the area under the ROC curve. Structure-function relationships were also similar for the two devices. In both groups, RNFL and macular thickness measurements were generally and in some cases significantly smaller with 3D OCT-1000 than with Stratus OCT.CONCLUSIONS: The introduction of FD technology did not lead to better discrimination ability for detecting BA of the optic nerve compared with TD technology when using the software currently provided by the manufacturer. 3D OCT-1000 FD OCT RNFL and macular measurements were generally smaller than TD Stratus OCT measurements. Investigators should be aware of this fact when comparing measurements obtained with these two devices. (Am J Oplathalmol 2009;147: 56-63. (c) 2009 by Elsevier Inc. All rights reserved.)