Low zinc intake affects maintenance of pregnancy in guinea pigs.
Low zinc intake affects maintenance of pregnancy in guinea pigs.
复制标题
锌摄入量低会影响豚鼠妊娠的维持。
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
G. Everett
中科院分区：
文献类型：
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作者：
J. Apgar;G. Everett
怀孕期间锌缺乏对动物有严重影响。目前尚不清楚动物中的影响在多大程度上适用于人类怀孕。因为怀孕的豚鼠与怀孕的妇女，使其成为一个有用的模型的特点，三个实验进行了与豚鼠，其中锌的摄入量减少，从妊娠第30天开始。在三个实验中的两个中，锌摄入量减少导致流产或早产。饲料摄入量仅限于缺锌动物的补锌动物也会流产或早产。补充锌的动物自由采食，在足月时产下活仔。与报告的其他动物相比，豚鼠的胎仔/新生儿肝脏锌浓度较低，受母体锌摄入量低的影响程度较小。新生儿血浆锌浓度也低于其他几个物种。血管紧张素转换酶活性的变化与锌在体外的锌缺乏豚鼠的血浆中比锌充足的豚鼠，可能是有用的锌状态的指标。
Zinc deficiency during pregnancy has severe effects in animals. To what extent the effects in animals apply to human pregnancy is not known. Because the pregnant guinea pig shares characteristics with pregnant women that make it a useful model, three experiments were done with guinea pigs in which Zn intake was reduced beginning on the 30th d of gestation. Reduced Zn intake in two of the three experiments resulted in abortion or premature delivery. Zinc-supplemented animals with feed intake restricted to that of Zn-deficient animals also aborted or delivered prematurely. Zinc-supplemented animals fed for ad libitum access delivered living young at term. Fetal/neonatal liver Zn concentration was low in the guinea pigs compared to that reported for other animals and was affected to a lesser extent by low Zn intake by the dam. Zinc concentration of neonatal plasma was also less than that in several other species. Change in activity of angiotensin-converting enzyme with addition of Zn in vitro was greater in the plasma of Zn-deficient guinea pigs than in that of Zn-adequate guinea pigs and may be useful as an indicator of Zn status.