Significance of Helicobacter pylori infection as a risk factor in gastric cancer: Serological and histological studies
Significance of Helicobacter pylori infection as a risk factor in gastric cancer: Serological and histological studies
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DOI：
10.1007/bf02934482
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发表时间：
1997-06-01
影响因子：
6.3
通讯作者：
Bernal, SF
中科院分区：
文献类型：
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作者：
BarretoZuniga, R;Maruyama, M;Bernal, SF
我们进行了一项病例对照研究，以检查幽门螺杆菌感染作为日本人群胃癌危险因素的相关性。在55例连续胃癌患者、75例年龄和性别匹配的大规模调查受试者和57例年龄和性别匹配的无癌患者中测定了幽门螺杆菌的血清IgG抗体，这些患者被认为是胃癌发展的高风险（癌前状态）。我们检查了所有受试者的组织学，并特别关注幽门螺杆菌相关性胃炎的程度。胃癌组和癌前病变组幽门螺杆菌阳性率分别为82%和89%，均显著高于普查组（60%）（P < 0.005）。胃癌患者（比值比为3，95%可信区间为1.69-5.33）和癌前病变患者（比值比为5.66，95%可信区间为2.66-12.03）的相对风险呈正相关。病例组与对照组比较，H。pylori阳性，有炎性细胞浸润（P = 0.0127）。组织学检查胃粘膜中幽门螺杆菌的特征在所有组中幽门螺杆菌感染者和未感染者之间显示出差异。然而，对于这些组中没有一个有显着差异的背景粘膜幽门螺杆菌感染的人或没有胃癌。幽门螺杆菌血清阳性率与胃癌风险增加和癌前状态密切相关;组织学研究未确定可能与癌症风险增加相关的其他因素。
We conducted a case-control study to examine the association of Helicobacter pylori infection as a risk factor in gastric cancer in the Japanese population. Serum IgG antibodies for Helicobacter pylori were determined in 55 consecutive patients with gastric cancer and in 75 age- and sex-matched mass survey subjects and 57 age- and sex-matched cancer-free patients with conditions considered at a high risk for development of gastric cancer (precancerous condition). We examined the histology in all subjects and particular focus was placed on the extent of Helicobacter pylori-associated gastritis. The seroprevalence of Helicobacter pylori in gastric cancer patients (82%) and those with a precancerous condition (89%) was significantly higher (P < 0.005) than that in the mass survey subjects (60%). Positive relative risk associations were found for patients with gastric cancer (odds ratio, 3, with 95% confidence intervals of 1.69-5.33) and those with a precancerous condition (odds ratio, 5.66, with 95% confidence intervals 2.66-12.03). Significant differences were found when comparisons were made among the case-control groups who were H. pylori-positive and had inflammatory cell infiltration (P = 0.0127). The characteristics of Helicobacter pylori in histologically examined gastric mucosa showed differences between Helicobacter pylori-infected and uninfected persons in all groups. However, for none of these groups was there a significant difference between background mucosa for Helicobacter pylori-infected persons with or without gastric cancer. Helicobacter pylori seroprevalence is strongly associated with an increased risk of gastric cancer and with a precancerous condition; histological investigation did not define additional factors that might be associated with increased cancer risk.