Formal Synthesis of Leustroducsin B
Formal Synthesis of Leustroducsin B
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DOI：
10.1055/s-0028-1083511
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发表时间：
2008-10-21
期刊：
影响因子：
2
通讯作者：
Cossy, Janine
中科院分区：
文献类型：
--
作者：
Moise, Joelle;Sonawane, Ravindra P.;Cossy, Janine
A formal synthesis of leustroducsin B, a potent antitumor compound, is described featuring two key reactions: an olefin cross-metathesis between alpha-methylene gamma-butyrolactone and a terminal olefin to install the C7-C12 carbon backbone, and a highly stereoselective Brown-type pentenylation which sets the syn-relationship between the two substituents at C4 and C5.
