Genetic risks to nicotine dependence predict negative mood and affect in current non-smokers.
Genetic risks to nicotine dependence predict negative mood and affect in current non-smokers.
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尼古丁依赖的遗传风险预示着当前不吸烟者的负面情绪和影响。
DOI：
10.1038/srep09521
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发表时间：
2015
影响因子：
4.6
通讯作者：
Eissenberg,Thomas
中科院分区：
文献类型：
--
作者：
Chen,Xiangning;Aggen,StevenH;Chen,Jingchun;Li,Lingxi;Kendler,KennethS;Blank,Melissa;Eissenberg,Thomas
尼古丁是尼古丁依赖中的精神活性剂。然而，尼古丁作为一种药物及其对人类心理的影响在遗传学研究中基本上没有得到充分的研究。在这项研究中，我们招募了208名目前的非吸烟者，以评估尼古丁的影响及其与尼古丁依赖遗传风险的关系。进行了探索性和验证性因素分析以及测量不变性检验，以评价3种尼古丁剂量下POMS、PANAS和DEN问卷的潜在因素结构。结构模型用于检查尼古丁的影响及其与尼古丁依赖遗传风险的关系。我们发现，尼古丁管理导致的测量结构和因素的手段的变化，表明尼古丁的心理反应的因果关系。rs588765的基因型预测了DEN混淆和头晕因子的评分（分别为p = 0.0003和0.001），rs16969968和rs588765与PANAS神经因子相关（分别为p = 0.006和0.007）。我们的研究表明，尼古丁依赖的遗传风险与急性心理反应有关。将心理测量学分析与剂量效应相结合可能是尼古丁依赖遗传学研究的一个有力途径。
Nicotine is the psychoactive agent involved in nicotine dependence. However, nicotine as a drug and its effects on human psychology are largely under-investigated in genetic studies. In this study, we recruited 208 current non-smokers to evaluate the effect of nicotine and its relationship to genetic risks to nicotine dependence. Exploratory and confirmatory factor analyses, as well as measurement invariance testing, were conducted to evaluate the latent factor structures of the POMS, PANAS and DEN questionnaires across 3 nicotine doses. Structural models were used to examine the effects of nicotine and their relationship to genetic risks of nicotine dependence. We found that nicotine administration led to the change of both measurement construct and factor means, indicating the causal effect of nicotine on the psychological responses. The genotypes of rs588765 predicted the scores of the DEN Confused and Dizzy factors (p = 0.0003 and 0.001 respectively) and rs16969968 and rs588765 were associated with the PANAS Nervous factor (p = 0.006 and 0.007 respectively). Our study suggested that genetic risk of nicotine dependence is associated with acute psychological responses. The integration of psychometric analyses and dose effects could be a powerful approach for genetic study of nicotine dependence.