Fear generalization immediately after contextual fear memory consolidation in mice
Fear generalization immediately after contextual fear memory consolidation in mice
复制标题
小鼠情境恐惧记忆巩固后立即出现恐惧泛化
DOI：
10.1016/j.bbrc.2021.04.072
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发表时间：
2021
影响因子：
3.1
通讯作者：
Sakaguchi Masanori
中科院分区：
文献类型：
--
作者：
Yu Jiahui;Naoi Toshie;Sakaguchi Masanori
恐惧泛化是焦虑相关疾病的症状，包括急性应激障碍和创伤后应激障碍。使用情境恐惧调节范式，我们发现，训练后不久暴露于类似中性情境但没有不同中性情境的小鼠在情境恐惧记忆巩固后（即训练后 6 小时）立即表现出恐惧泛化。这种恐惧泛化不仅体现在总量的变化上，还体现在条件环境和泛化环境之间的冻结模式上。这些结果提供了对影响恐惧泛化的因素的深入了解，并可以促进未来研究焦虑相关疾病的潜在病理生理机制。
Fear generalization is a symptom of anxiety-related disorders, including acute stress disorder and post-traumatic stress disorder. Using a contextual fear conditioning paradigm, we found that mice exposed to a similar neutral context but not a different neutral context soon after training showed fear generalization immediately after contextual fear memory consolidation (i.e., 6 h after training). This fear generalization was reflected by a change not only in the total amount but also the pattern of freezing between conditioned and generalized contexts. These results provide insight into the factors that influence fear generalization and can facilitate future studies investigating the underlying pathophysiological mechanisms of anxiety-related disorders.