CLONING, EXPRESSION AND LOCALIZATION OF AN RNA HELICASE GENE FROM A HUMAN LYMPHOID-CELL LINE WITH CHROMOSOMAL BREAKPOINT 11Q23.3
CLONING, EXPRESSION AND LOCALIZATION OF AN RNA HELICASE GENE FROM A HUMAN LYMPHOID-CELL LINE WITH CHROMOSOMAL BREAKPOINT 11Q23.3
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DOI：
10.1093/nar/20.8.1967
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发表时间：
1992-04-25
影响因子：
14.9
通讯作者：
YUNIS, JJ
中科院分区：
文献类型：
--
作者：
DAN, L;YUNIS, JJ
编码假定的人类 RNA 解旋酶 p54 的基因已被克隆并定位到 11 号染色体的 q23.3 条带。预测的氨基酸序列与果蝇雌性种系特异性 RNA 解旋酶 ME31B 基因具有惊人的同源性（75% 相同）。然而，与 ME31B 不同的是，新基因在大量成体组织中表达丰富的转录物，并且发现其 5' 非编码区在来自弥漫性大 B 细胞淋巴瘤的 t(11;14)(q23.3;q32.3) 细胞系中分裂。
A gene encoding a putative human RNA helicase, p54, has been cloned and mapped to the band q23.3 of chromosome 11. The predicted amino acid sequence shares a striking homology (75% identical) with the female germline-specific RNA helicase ME31B gene of Drosophila. Unlike ME31B, however, the new gene expresses an abundant transcript in a large number of adult tissues and its 5' non-coding region was found split in a t(11;14)(q23.3;q32.3) cell line from a diffuse large B-cell lymphoma.