EFFECT OF PROLONGED EXERCISE ON THE LEVEL OF TRIGLYCERIDES IN THE RAT-LIVER
EFFECT OF PROLONGED EXERCISE ON THE LEVEL OF TRIGLYCERIDES IN THE RAT-LIVER
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DOI：
10.1007/bf00418461
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发表时间：
1988-05-01
影响因子：
3
通讯作者：
PUCH, U
中科院分区：
文献类型：
--
作者：
GORSKI, J;NOWACKA, M;PUCH, U
本研究考察了长时间运动对大鼠肝脏甘油三酯（TG）水平的影响。将大鼠分为：1-对照组，2-烟酸组，3-运动时葡萄糖组，4-禁食组，5-肾上腺切除组，6-肾上腺切除组和油组。在对照组中，肝脏中TG逐渐积累，疲劳时其水平比静息值增加了一倍。烟酸降低了静息时的TG水平，并阻止了它们在运动中的积累。运动期间葡萄糖的管理部分阻止了肝脏中TG水平的增加。运动前禁食24 h的大鼠，运动期间肝脏TG的净升高量与对照组相似。肾上腺切除术，就像烟酸一样，降低了休息时的TG水平，并阻止了运动时的升高。给去肾上腺的大鼠喂油提高了血浆游离脂肪酸水平，但在休息或运动时都没有导致肝脏中TG的积累。结论是，长时间的运动导致肝脏中TG的积累，而这一过程取决于游离脂肪酸和葡萄糖的供应，并需要糖皮质激素的存在。
This study examined the effect of prolonged exercise on the level of triglycerides (TG) in rat liver. The rats were divided into groups: 1-control, 2-treated with nicotinic acid, 3-fed with glucose during exercise, 4-fasted, 5-adrenalectomized, 6-adrenalectomized and fed with oil. In the control group, there was gradual accumulation of TG in the liver and their level was doubled at exhaustion as compared to the resting value. Nicotinic acid lowered the resting level of TG and prevented their accumulation during exercise. Administration of glucose during exercise partially prevented the increase in TG level in the liver. In rats fasted for 24 h before exercise, the net increased in liver TG level during exercise was similar to that in the controls. Adrenalectomy, like nicotinic acid, lowered TG level at rest and prevented its increase during exercise. Feeding the adrenalectomized rats with oil elevated the plasma free fatty acid level but did not result in accumulation of TG in the liver, either at rest or during exercise. It is concluded that prolonged exercise results in accumulation of TG in the liver and that the process depends on the supply of free fatty acids and glucose and requires the presence of glucocorticoids.