C-13 MAGNETIC-RESONANCE .26. QUANTITATIVE-DETERMINATION OF TAUTOMERIC POPULATIONS OF CERTAIN PURINES
C-13 MAGNETIC-RESONANCE .26. QUANTITATIVE-DETERMINATION OF TAUTOMERIC POPULATIONS OF CERTAIN PURINES
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DOI：
10.1021/ja00849a028
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发表时间：
1975-01-01
影响因子：
15
通讯作者：
TOWNSEND, LB
中科院分区：
文献类型：
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作者：
CHENON, MT;PUGMIRE, RJ;TOWNSEND, LB
用嘌呤的α和β碳-13化学位移取代基参数研究了该环体系中的互变异构体。该程序允许定量测定嘌呤（I）、腺嘌呤（II）、次黄嘌呤（III）、6-巯基嘌呤（VI）和某些相关嘌呤的主要互变异构形式。这项研究包括质子转移的互变异构现象的咪唑部分，以及内酰胺-内酰亚胺或硫酮-巯基互变异构现象的嘧啶部分的嘌呤环。
The a and ß carbon-13 chemical shift substituent parameters obtained for purines have been employed to investigate the tautomeric populations in thisring system. This procedure allows a quantitative determination of the predominant tautomeric forms of purine (I), adenine (II), hypoxanthine (III), 6-mercaptopurine (VI), and certain related purines. The study encompasses prototropic tautomerism in the imidazole moiety as well as lactam-lactim or thione-thiol tautomerism in the pyrimidine portion of the purine ring.