Inhibitory control and trait aggression: Neural and behavioral insights using the emotional stop signal task
Inhibitory control and trait aggression: Neural and behavioral insights using the emotional stop signal task
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DOI：
10.1016/j.neuroimage.2013.04.104
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发表时间：
2013-10-01
期刊：
影响因子：
5.7
通讯作者：
Habel, Ute
中科院分区：
文献类型：
--
作者：
Pawliczek, Christina M.;Derntl, Birgit;Habel, Ute
反应抑制的缺陷和冲动性的增强与精神疾病和攻击性有关。他们已经在临床群体以及个人的特质特征进行了调查，深入了解反应抑制和冲动的潜在神经和行为机制。本研究从550名男性中选择了高特质攻击组（HA，n = 17）和低特质攻击组（LA，n = 16），进行fMRI研究。将神经激活与停止信号任务的情感版本（包括愤怒和中性面孔）进行比较。行为结果显示HA的反应抑制受损，与更高的运动冲动相关。这伴随着参与反应抑制的大脑区域的激活减弱，包括前补充运动区（SMA）和运动皮层。总之，这些发现提供了证据，表明HA中存在抑制能力降低。值得注意的是，在愤怒试验中，两组的反应抑制都有所改善，这表明通过提高相关大脑区域的激活而产生了促进效应。在这两个群体中，列入愤怒刺激增强了激活的运动和躯体感觉区，调节执行控制，和边缘系统的地区，包括amygdala.In总结，调查的反应抑制在个人的高和低的特质特征提供了有用的见解，潜在的不同的处理机制。它可以有助于在临床背景下调查性状标记，而不必处理临床疾病本身的复杂机制。相比之下，情绪反应抑制的机制在各组之间没有差异。因此，特定的情绪影响与特质攻击没有相互作用。(C)2013 Elsevier Inc. All rights reserved.
Deficits in response inhibition and heightened impulsivity have been linked to psychiatric disorders and aggression. They have been investigated in clinical groups as well as individuals with trait characteristics, yielding insights into the underlying neural and behavioral mechanisms of response inhibition and impulsivity. The motor inhibition tasks employed in most studies, however, have lacked an emotional component, which is crucial given that both response inhibition and impulsivity attain salience within a socio-emotional context.For this fMRI study, we selected a group with high trait aggression (HA, n = 17) and one with low trait aggression (LA, n = 16) from 550 males who had completed an Aggression Questionnaire. Neural activation was compared to an emotional version (including angry and neutral faces) of the stop signal task.Behavioral results revealed impaired response inhibition in HA, associated with higher motor impulsivity. This was accompanied by attenuated activation in brain regions involved in response inhibition, including the pre-supplementary motor area (SMA) and motor cortex. Together, these findings offer evidence that a reduced inhibition capacity is present in HA. Notably, response inhibition improved during anger trials in both groups, suggesting a facilitation effect through heightened activation in the related brain regions. In both groups, inclusion of the anger stimuli enhanced the activation of the motor and somatosensory areas, which modulate executive control, and of limbic regions including the amygdala.In summary, the investigation of response inhibition in individuals with high and low trait characteristics affords useful insights into the underlying distinct processing mechanisms. It can contribute to the investigation of trait markers in a clinical context without having to deal with the complex mechanisms of a clinical disorder itself. In contrast, the mechanisms of emotional response inhibition did not differ between groups. Hence, the specific emotional influence is not interacting with trait aggression. (C) 2013 Elsevier Inc. All rights reserved.